Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	700	1q41	CAPN2	calpain 2
Mouse	-	700	1 H5	Capn2	calpain 2
Rat	-	700	13q26	Capn2	calpain 2

Previous and Unofficial Names

80 kDa M-calpain subunit | calcium-activated neutral proteinase 2 | CALP80 | calpain M-type | calpain-2 catalytic subunit | CANP 2 | Capa2 | m-calpain | millimolar-calpain | calpain 2, (m/II) large subunit

Database Links
Specialist databases
MEROPS	C02.002 (Hs)
Other databases
Alphafold	P17655 (Hs), O08529 (Mm), Q07009 (Rn)
BRENDA	3.4.22.53
ChEMBL Target	CHEMBL2382 (Hs)
Ensembl Gene	ENSG00000162909 (Hs), ENSMUSG00000026509 (Mm), ENSRNOG00000034015 (Rn)
Entrez Gene	824 (Hs), 12334 (Mm), 29154 (Rn)
Human Protein Atlas	ENSG00000162909 (Hs)
KEGG Enzyme	3.4.22.53
KEGG Gene	hsa:824 (Hs), mmu:12334 (Mm), rno:29154 (Rn)
OMIM	114230 (Hs)
Pharos	P17655 (Hs)
RefSeq Nucleotide	NM_001146068 (Hs), NM_001748 (Hs), NM_009794 (Mm), NM_017116 (Rn)
RefSeq Protein	NP_001739 (Hs), NP_001139540 (Hs), NP_033924 (Mm), NP_058812 (Rn)
UniProtKB	P17655 (Hs), O08529 (Mm), Q07009 (Rn)
Wikipedia	CAPN2 (Hs)

Enzyme Reaction
EC Number: 3.4.22.53

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 5a [PMID: 20690647] Pig Inhibition 7.2 pKi 2 ⤷ pKi 7.2 (Ki 6.8x10-8 M) [2] compound 19 [PMID: 8831774] Hs Inhibition 7.8 pIC50 1 ⤷ pIC50 7.8 (IC50 1.5x10-8 M) [1]
View species-specific inhibitor tables

Immuno Process Associations

Immuno Process:  Cytokine production & signalling