Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	732	3p21.31	APEH	acylaminoacyl-peptide hydrolase
Mouse	-	732	9 59.07 cM	Apeh	acylpeptide hydrolase
Rat	-	732	8q32	Apeh	acylaminoacyl-peptide hydrolase

Previous and Unofficial Names

AARE | acyl-peptide hydrolase | APH | acylamino-acid-releasing enzyme | APEH

Database Links
Specialist databases
MEROPS	S09.004 (Hs)
Other databases
Alphafold	P13798 (Hs), Q8R146 (Mm), P13676 (Rn)
BRENDA	3.4.19.1
CATH/Gene3D	3.40.50.1820
ChEMBL Target	CHEMBL1741174 (Hs), CHEMBL2189142 (Mm)
Ensembl Gene	ENSG00000164062 (Hs), ENSMUSG00000032590 (Mm), ENSRNOG00000029572 (Rn)
Entrez Gene	327 (Hs), 235606 (Mm), 24206 (Rn)
Human Protein Atlas	ENSG00000164062 (Hs)
KEGG Enzyme	3.4.19.1
KEGG Gene	hsa:327 (Hs), mmu:235606 (Mm), rno:24206 (Rn)
OMIM	102645 (Hs)
Pharos	P13798 (Hs)
RefSeq Nucleotide	NM_001640 (Hs), NM_146226 (Mm), NM_012500 (Rn)
RefSeq Protein	NP_001631 (Hs), NP_666338 (Mm), NP_036632 (Rn)
UniProtKB	P13798 (Hs), Q8R146 (Mm), P13676 (Rn)
Wikipedia	APEH (Hs)

Enzyme Reaction
EC Number: 3.4.19.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference ARI-3099 Hs Inhibition 7.0 pIC50 1 ⤷ pIC50 7.0 (IC50 1.04x10-7 M) [1] Description: Substrate (Ac-Ala-AMC) assay.

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Cellular signalling