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Target not currently curated in GtoImmuPdb
Target id: 2095
Nomenclature: MAPK activated protein kinase 3
Abbreviated Name: MAPKAPK3
Family: MAPKAPK subfamily
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 382 | 3p21.2 | MAPKAPK3 | MAPK activated protein kinase 3 | |
Mouse | - | 384 | 9 F1 | Mapkapk3 | mitogen-activated protein kinase-activated protein kinase 3 | |
Rat | - | 384 | 8q32 | Mapkapk3 | MAPK activated protein kinase 3 |
Previous and Unofficial Names |
MAPKAP kinase 3 | mitogen-activated protein kinase-activated protein kinase 3 |
Database Links | |
Alphafold | Q16644 (Hs), Q3UMW7 (Mm), Q66H84 (Rn) |
BRENDA | 2.7.11.1 |
CATH/Gene3D | 4.10.1170.10 |
ChEMBL Target | CHEMBL4670 (Hs) |
Ensembl Gene | ENSG00000114738 (Hs), ENSMUSG00000032577 (Mm), ENSRNOG00000014832 (Rn) |
Entrez Gene | 7867 (Hs), 102626 (Mm), 315994 (Rn) |
Human Protein Atlas | ENSG00000114738 (Hs) |
KEGG Enzyme | 2.7.11.1 |
KEGG Gene | hsa:7867 (Hs), mmu:102626 (Mm), rno:315994 (Rn) |
OMIM | 602130 (Hs) |
Pharos | Q16644 (Hs) |
RefSeq Nucleotide | NM_001243925 (Hs), NM_178907 (Mm), NM_001012127 (Rn) |
RefSeq Protein | NP_004626 (Hs), NP_849238 (Mm), NP_001012127 (Rn) |
UniProtKB | Q16644 (Hs), Q3UMW7 (Mm), Q66H84 (Rn) |
Wikipedia | MAPKAPK3 (Hs) |
Selected 3D Structures | |||||||||||
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Enzyme Reaction | ||||
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: 1,4 |
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Key to terms and symbols | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Target used in screen: MAPKAP-K3/MAPKAPK3 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
Immuno Process Associations | ||
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1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1039-45. [PMID:22037377]
2. Anderson DR, Meyers MJ, Vernier WF, Mahoney MW, Kurumbail RG, Caspers N, Poda GI, Schindler JF, Reitz DB, Mourey RJ. (2007) Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J Med Chem, 50 (11): 2647-54. [PMID:17480064]
3. Cheng R, Felicetti B, Palan S, Toogood-Johnson I, Scheich C, Barker J, Whittaker M, Hesterkamp T. (2010) High-resolution crystal structure of human Mapkap kinase 3 in complex with a high affinity ligand. Protein Sci, 19 (1): 168-73. [PMID:19937655]
4. Gao Y, Davies SP, Augustin M, Woodward A, Patel UA, Kovelman R, Harvey KJ. (2013) A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. Biochem J, 451 (2): 313-28. [PMID:23398362]
MAPKAPK subfamily: MAPK activated protein kinase 3. Last modified on 30/04/2019. Accessed on 06/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2095.