Contents:
Gene and Protein Information  |
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| Adhesion G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 1459 | 1p31.1 | ADGRL2 | adhesion G protein-coupled receptor L2 | |
| Mouse | 7 | 1487 | 3 H3 | Adgrl2 | adhesion G protein-coupled receptor L2 | |
| Rat | 7 | 1487 | 2q45 | Adgrl2 | adhesion G protein-coupled receptor L2 | |
| Previous and Unofficial Names |
| LPHN2 (latrophilin 2) | LPHH1 (latrophilin homologue in humans 1) | LEC1 (lectomedin-1) | CIRL2 (calcium-independent receptor of alpha-latrotoxin 2) |
| Database Links |
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| Specialist databases | |
| GPCRdb | agrl2_human (Hs), agrl2_rat (Rn) |
| Other databases | |
| Alphafold | O95490 (Hs), Q8JZZ7 (Mm), O88923 (Rn) |
| Ensembl Gene | ENSG00000117114 (Hs), ENSMUSG00000028184 (Mm), ENSRNOG00000065347 (Rn), ENSRNOG00000063253 (Rn) |
| Entrez Gene | 23266 (Hs), 99633 (Mm), 171447 (Rn) |
| Human Protein Atlas | ENSG00000117114 (Hs) |
| KEGG Gene | hsa:23266 (Hs), mmu:99633 (Mm), rno:171447 (Rn) |
| OMIM | 607018 (Hs) |
| Pharos | O95490 (Hs) |
| RefSeq Nucleotide | NM_012302 (Hs), NM_001081298 (Mm), NM_134408 (Rn) |
| RefSeq Protein | NP_036434 (Hs), NP_001074767 (Mm), NP_599235 (Rn) |
| UniProtKB | O95490 (Hs), Q8JZZ7 (Mm), O88923 (Rn) |
| Wikipedia | ADGRL2 (Hs) |
| Associated Protein Comments | ||
| Extracellular and transmembrane interactors: FLRT-3 [12], teneurin-2 [9]. |
Download all structure-activity data for this target as a CSV file 
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| Tissue Distribution
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| Expression Datasets |
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| Xenobiotics Influencing Gene Expression
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| Gene Expression and Pathophysiology Comments | |
| ADGRL2 mRNA is dysregulated (up or down) in various cancers [15]. More information on the dysregulation of ADGRL2 in cancer can be found on the NCBI Geoprofiles database (http://www.ncbi.nlm.nih.gov/geoprofiles). |
| General Comments |
| ADGRL2 (formerly LPHN2, latrophilin 2) is an orphan receptor that belongs to Family I Adhesion-GPCRs along with ADGRL1 (latrophilin 1), ADGRL3 (latrophilin 3) and ADGRL4 (ELTD1) [2]. Family I Adhesion-GPCRs have orthologs in vertebrate and invertebrate species. |
References
1. Beyer RP, Fry RC, Lasarev MR, McConnachie LA, Meira LB, Palmer VS, Powell CL, Ross PK, Bammler TK, Bradford BU et al.. (2007) Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses. Toxicol Sci, 99 (1): 326-37. [PMID:17562736]
2. Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB. (2004) The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics, 84 (1): 23-33. [PMID:15203201]
3. de Wilde J, Mohren R, van den Berg S, Boekschoten M, Dijk KW, de Groot P, Müller M, Mariman E, Smit E. (2008) Short-term high fat-feeding results in morphological and metabolic adaptations in the skeletal muscle of C57BL/6J mice. Physiol Genomics, 32 (3): 360-9. [PMID:18042831]
4. Deaciuc IV, Arteel GE, Peng X, Hill DB, McClain CJ. (2004) Gene expression in the liver of rats fed alcohol by means of intragastric infusion. Alcohol, 33 (1): 17-30. [PMID:15353170]
5. Dillman 3rd JF, Phillips CS, Dorsch LM, Croxton MD, Hege AI, Sylvester AJ, Moran TS, Sciuto AM. (2005) Genomic analysis of rodent pulmonary tissue following bis-(2-chloroethyl) sulfide exposure. Chem Res Toxicol, 18 (1): 28-34. [PMID:15651846]
6. Györffy B, Surowiak P, Kiesslich O, Denkert C, Schäfer R, Dietel M, Lage H. (2006) Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer, 118 (7): 1699-712. [PMID:16217747]
7. Haitina T, Olsson F, Stephansson O, Alsiö J, Roman E, Ebendal T, Schiöth HB, Fredriksson R. (2008) Expression profile of the entire family of Adhesion G protein-coupled receptors in mouse and rat. BMC Neurosci, 9: 43. [PMID:18445277]
8. Ichtchenko K, Bittner MA, Krasnoperov V, Little AR, Chepurny O, Holz RW, Petrenko AG. (1999) A novel ubiquitously expressed alpha-latrotoxin receptor is a member of the CIRL family of G-protein-coupled receptors. J Biol Chem, 274 (9): 5491-8. [PMID:10026162]
9. Jackson VA, Meijer DH, Carrasquero M, van Bezouwen LS, Lowe ED, Kleanthous C, Janssen BJC, Seiradake E. (2018) Structures of Teneurin adhesion receptors reveal an ancient fold for cell-cell interaction. Nat Commun, 9 (1): 1079. [PMID:29540701]
10. Matsushita H, Lelianova VG, Ushkaryov YA. (1999) The latrophilin family: multiply spliced G protein-coupled receptors with differential tissue distribution. FEBS Lett, 443 (3): 348-52. [PMID:10025961]
11. Naciff JM, Jump ML, Torontali SM, Carr GJ, Tiesman JP, Overmann GJ, Daston GP. (2002) Gene expression profile induced by 17alpha-ethynyl estradiol, bisphenol A, and genistein in the developing female reproductive system of the rat. Toxicol Sci, 68 (1): 184-99. [PMID:12075121]
12. O'Sullivan ML, de Wit J, Savas JN, Comoletti D, Otto-Hitt S, Yates 3rd JR, Ghosh A. (2012) FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development. Neuron, 73 (5): 903-10. [PMID:22405201]
13. Regard JB, Sato IT, Coughlin SR. (2008) Anatomical profiling of G protein-coupled receptor expression. Cell, 135 (3): 561-71. [PMID:18984166]
14. Sugita S, Ichtchenko K, Khvotchev M, Südhof TC. (1998) alpha-Latrotoxin receptor CIRL/latrophilin 1 (CL1) defines an unusual family of ubiquitous G-protein-linked receptors. G-protein coupling not required for triggering exocytosis. J Biol Chem, 273 (49): 32715-24. [PMID:9830014]
15. White GR, Varley JM, Heighway J. (1998) Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer. Oncogene, 17 (26): 3513-9. [PMID:10030676]
How to cite this page
Arac-Ozkan D, Aust G, Bonner TI, Cappallo-Obermann H, Formstone C, Hamann J, Harty B, Heyne H, Kirchhoff C, Knapp B, Krishnan A, Langenhan T, Le Duc D, Lin HH, Martinelli DC, Monk K, Piao X, Prömel S, Schiöth H, Schöneberg T, Singer K, Stacey M, Ushkaryov Y, Wolfrum U, Xu L. Adhesion Class GPCRs in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F17/2023.1.
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