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ciliogenesis associated kinase 1

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Target not currently curated in GtoImmuPdb

Target id: 2038

Nomenclature: ciliogenesis associated kinase 1

Abbreviated Name: ICK

Family: RCK family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 632 6p12.1 CILK1 ciliogenesis associated kinase 1
Mouse - 629 9 E1 Cilk1 ciliogenesis associated kinase 1
Rat - 629 8q31 Cilk1 ciliogenesis associated kinase 1
Previous and Unofficial Names Click here for help
ICK | Ick | intestinal cell kinase | intestinal cell (MAK-like) kinase | Laryngeal cancer kinase 2 | LCK2
Database Links Click here for help
Alphafold Q9UPZ9 (Hs), Q9JKV2 (Mm), Q62726 (Rn)
BRENDA 2.7.11.22
ChEMBL Target CHEMBL1163126 (Hs)
Ensembl Gene ENSG00000112144 (Hs), ENSMUSG00000009828 (Mm), ENSRNOG00000008691 (Rn)
Entrez Gene 22858 (Hs), 56542 (Mm), 84411 (Rn)
Human Protein Atlas ENSG00000112144 (Hs)
KEGG Enzyme 2.7.11.22
KEGG Gene hsa:22858 (Hs), mmu:56542 (Mm), rno:84411 (Rn)
OMIM 612325 (Hs)
Orphanet ORPHA201496 (Hs)
Pharos Q9UPZ9 (Hs)
RefSeq Nucleotide NM_014920 (Hs), NM_001163780 (Mm), NM_138886 (Rn)
RefSeq Protein NP_055735 (Hs), NP_001157252 (Mm), NP_620241 (Rn)
UniProtKB Q9UPZ9 (Hs), Q9JKV2 (Mm), Q62726 (Rn)
Wikipedia CILK1 (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.22
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2
Key to terms and symbols Click column headers to sort
Target used in screen: ICK
Ligand Sp. Type Action Value Parameter
alvocidib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 9.2 pKd
R547 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.7 pKd
AT-7519 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.1 pKd
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.8 pKd
lestaurtinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 7.4 pKd
BMS-387032 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.8 pKd
ruboxistaurin Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.6 pKd
PHA-665752 Small molecule or natural product Hs Inhibitor Inhibition 6.4 pKd
sunitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 6.3 pKd
A-674563 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.3 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Endocrine-cerebroosteodysplasia
Synonyms: Endocrine-cerebro-osteodysplasia syndrome [Orphanet: ORPHA199332]
OMIM: 612651
Orphanet: ORPHA199332

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

RCK family: ciliogenesis associated kinase 1. Last modified on 12/11/2019. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2038.