RTP Type F | Receptor tyrosine phosphatase (RTP) family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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RTP Type F

Target not currently curated in GtoImmuPdb

Target id: 1855

Nomenclature: RTP Type F

Family: Receptor tyrosine phosphatase (RTP) family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - PTPRF protein tyrosine phosphatase receptor type F
Mouse - - Ptprf protein tyrosine phosphatase, receptor type, F
Rat - - Ptprf protein tyrosine phosphatase, receptor type, F
Previous and Unofficial Names
LARFN5C | leukocyte antigen-related (LAR) PTP receptor | protein tyrosine phosphatase, receptor type, F | protein tyrosine phosphatase | protein tyrosine phosphatase, receptor type F
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
Putative endogenous ligands
netrin-G3 ligand (LRRC4B, Q9NT99)  [1]

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
illudalic acid Hs Inhibition 5.9 pIC50 2
pIC50 5.9 (IC50 1.3x10-6 M) [2]
Description: Measured utilising purified recombinant LAR catalytic domain.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0001960 negative regulation of cytokine-mediated signaling pathway ISO


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1. Kwon SK, Woo J, Kim SY, Kim H, Kim E. (2010) Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation. J. Biol. Chem., 285 (18): 13966-78. [PMID:20139422]

2. Ling Q, Huang Y, Zhou Y, Cai Z, Xiong B, Zhang Y, Ma L, Wang X, Li X, Li J et al.. (2008) Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action. Bioorg. Med. Chem., 16 (15): 7399-409. [PMID:18579388]

How to cite this page

Receptor tyrosine phosphatase (RTP) family: RTP Type F. Last modified on 15/09/2015. Accessed on 07/07/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1855.