Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	1912	9p24.1-p23	PTPRD	protein tyrosine phosphatase receptor type D
Mouse	1	1912	4 36.94 cM	Ptprd	protein tyrosine phosphatase receptor type D
Rat	-	-		Ptprd	protein tyrosine phosphatase, receptor type, D

Previous and Unofficial Names

HPTP | protein tyrosine phosphatase, receptor type, D | protein tyrosine phosphatase | protein tyrosine phosphatase, receptor type D

Database Links
Alphafold	P23468 (Hs), Q64487 (Mm)
CATH/Gene3D	3.90.190.10, 2.60.40.10
Ensembl Gene	ENSG00000153707 (Hs), ENSMUSG00000028399 (Mm), ENSRNOG00000005711 (Rn)
Entrez Gene	5789 (Hs), 19266 (Mm), 313278 (Rn)
Human Protein Atlas	ENSG00000153707 (Hs)
KEGG Gene	hsa:5789 (Hs), mmu:19266 (Mm), rno:313278 (Rn)
OMIM	601598 (Hs)
Pharos	P23468 (Hs)
UniProtKB	P23468 (Hs), Q64487 (Mm)
Wikipedia	PTPRD (Hs)

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference 7-BIA Hs Inhibition 5.5 – 6.0 pIC50 1 ⤷ pIC50 5.5 – 6.0 (IC50 3x10-6 – 1x10-6 M) [1] Description: Inhibition of p-nitrophenyl phosphate dephosphorylation by recombinant PTPRD phosphatase domain fusion protein following 16-18 minute preincubation.

Immuno Process Associations

Immuno Process:  Immune regulation GO Annotations:  Associated to 1 GO processes, IEA only click arrow to show/hide IEA associations GO:0050776 regulation of immune response IEA

Physiological Consequences of Altering Gene Expression
Heterozygous mouse Ptprd knockouts (i.e. mice with reduced Ptprd expression) show reduced addictive behaviour in cocaine self-administration experiments than their wild-type littermates. Species:  Mouse Tissue:  Technique:  References:  1

General Comments
PTPRD is being investigated as a target for the development of antiaddiction therapeutics [1].