Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	1024	2p22.3	NLRC4	NLR family CARD domain containing 4
Mouse	-	1024	17 E2	Nlrc4	NLR family, CARD domain containing 4
Rat	-	1023	6q13	Nlrc4	NLR family

Previous and Unofficial Names

NOD4 | caspase recruitment domain family, member 12 | NOD-like receptor C4 | NLR family, CARD domain containing 4 | CARD12 | CLAN | CLAN1 | CLANA | CLANB | CLANC | CLAND | CLR2.1 | IPAF | NLR family

Database Links
Alphafold	Q9NPP4 (Hs), Q3UP24 (Mm), F1M649 (Rn)
CATH/Gene3D	3.80.10.10
ChEMBL Target	CHEMBL4630857 (Hs), CHEMBL4295841 (Mm)
Ensembl Gene	ENSG00000091106 (Hs), ENSMUSG00000039193 (Mm), ENSRNOG00000005810 (Rn)
Entrez Gene	58484 (Hs), 268973 (Mm), 298784 (Rn)
Human Protein Atlas	ENSG00000091106 (Hs)
KEGG Gene	hsa:58484 (Hs), mmu:268973 (Mm), rno:298784 (Rn)
OMIM	606831 (Hs)
Pharos	Q9NPP4 (Hs)
UniProtKB	Q9NPP4 (Hs), Q3UP24 (Mm), F1M649 (Rn)
Wikipedia	NLRC4 (Hs)

Immunopharmacology Comments

As part of the innate inflammatory response to invading mobile bacteria, NLRC4 (Ipaf) in macrophages induces a pro-inflammatory response upon detection of cytosolic bacterial flagellin. In contrast, extracellular bacterial flagellin is detected by TLR5 [1].

Immuno Process Associations

Immuno Process:  Inflammation GO Annotations:  Associated to 5 GO processes GO:0002218 activation of innate immune response ISS GO:0002221 pattern recognition receptor signaling pathway IC GO:0006954 inflammatory response ISS GO:0050729 positive regulation of inflammatory response IC click arrow to show/hide IEA associations GO:0045087 innate immune response IEA

Immuno Process:  Immune regulation GO Annotations:  Associated to 3 GO processes GO:0002218 activation of innate immune response ISS GO:0002221 pattern recognition receptor signaling pathway IC GO:0050729 positive regulation of inflammatory response IC

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 1 GO processes GO:0032731 positive regulation of interleukin-1 beta production IGI

Physiological Functions Comments

Involved in inflammasome formation and caspase-1 activation. Co-operates with NAIP proteins to form an inflammasome.

Clinically-Relevant Mutations and Pathophysiology
Disease:  Autoinflammation with infantile enterocolitis; AIFEC OMIM: 616050
Disease:  Familial cold autoinflammatory syndrome 4; FCAS4 OMIM: 616115