NLRC4 | NOD-like receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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  Target has curated data in GtoImmuPdb

Target id: 1782

Nomenclature: NLRC4

Family: NOD-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1024 2p22.3 NLRC4 NLR family CARD domain containing 4
Mouse - 1024 17 45.64 cM Nlrc4 NLR family, CARD domain containing 4
Rat - 1023 6 q12 Nlrc4 NLR family, CARD domain containing 4
Previous and Unofficial Names
NOD4 | caspase recruitment domain family, member 12 | NOD-like receptor C4 | NLR family, CARD domain containing 4 | IPAF | CARD12 | CLAN | CLAN1 | CLANA | CLANB | CLANC | CLAND | CLR2.1 | NLR family
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
Immunopharmacology Comments
As part of the innate inflammatory response to invading mobile bacteria, NLRC4 (Ipaf) in macrophages induces a pro-inflammatory response upon detection of cytosolic bacterial flagellin. In contrast, extracellular bacterial flagellin is detected by TLR5 [1].
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0002218 activation of innate immune response ISS
GO:0006954 inflammatory response ISS
click arrow to show/hide IEA associations
GO:0045087 innate immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0002218 activation of innate immune response ISS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0050702 interleukin-1 beta secretion IDA
Physiological Functions Comments
Involved in inflammasome formation and caspase-1 activation. Co-operates with NAIP proteins to form an inflammasome.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Autoinflammation with infantile enterocolitis; AIFEC
OMIM: 616050
Disease:  Familial cold autoinflammatory syndrome 4; FCAS4
OMIM: 616115


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1. Miao EA, Andersen-Nissen E, Warren SE, Aderem A. (2007) TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system. Semin Immunopathol, 29 (3): 275-88. [PMID:17690885]


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