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Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 1024 | 2p22.3 | NLRC4 | NLR family CARD domain containing 4 | |
Mouse | - | 1024 | 17 E2 | Nlrc4 | NLR family, CARD domain containing 4 | |
Rat | - | 1023 | 6q13 | Nlrc4 | NLR family, CARD domain containing 4 |
Database Links | |
Alphafold | Q9NPP4 (Hs), Q3UP24 (Mm), F1M649 (Rn) |
CATH/Gene3D | 3.80.10.10 |
ChEMBL Target | CHEMBL4630857 (Hs), CHEMBL4295841 (Mm) |
Ensembl Gene | ENSG00000091106 (Hs), ENSMUSG00000039193 (Mm), ENSRNOG00000005810 (Rn) |
Entrez Gene | 58484 (Hs), 268973 (Mm), 298784 (Rn) |
Human Protein Atlas | ENSG00000091106 (Hs) |
KEGG Gene | hsa:58484 (Hs), mmu:268973 (Mm), rno:298784 (Rn) |
OMIM | 606831 (Hs) |
Pharos | Q9NPP4 (Hs) |
UniProtKB | Q9NPP4 (Hs), Q3UP24 (Mm), F1M649 (Rn) |
Wikipedia | NLRC4 (Hs) |
Immunopharmacology Comments |
As part of the innate inflammatory response to invading mobile bacteria, NLRC4 (Ipaf) in macrophages induces a pro-inflammatory response upon detection of cytosolic bacterial flagellin. In contrast, extracellular bacterial flagellin is detected by TLR5 [1]. |
Immuno Process Associations | ||
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Physiological Functions Comments | |
Involved in inflammasome formation and caspase-1 activation. Co-operates with NAIP proteins to form an inflammasome. |
Clinically-Relevant Mutations and Pathophysiology | ||||||||
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