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NLRP12

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Target not currently curated in GtoImmuPdb

Target id: 1779

Nomenclature: NLRP12

Family: NOD-like receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1061 19q13.42 NLRP12 NLR family pyrin domain containing 12
Mouse - 1054 7 A1 Nlrp12 NLR family, pyrin domain containing 12
Rat - - 1q12 Nlrp12 NLR family, pyrin domain containing 12
Previous and Unofficial Names Click here for help
CLR19.3 | NALP12 | PAN6 | PYPAF7 | RNO2 | NACHT, leucine rich repeat and PYD containing 12 | Monarch1 | FCAS2 | RNO | NLR family | NLR family, pyrin domain containing 12
Database Links Click here for help
Alphafold
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Immuno Process Associations
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0036336 dendritic cell migration IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 6 GO processes
GO:0001818 negative regulation of cytokine production IDA
GO:0032661 regulation of interleukin-18 production NAS
GO:0032692 negative regulation of interleukin-1 production IDA
GO:0032715 negative regulation of interleukin-6 production IDA
GO:0032731 positive regulation of interleukin-1 beta production NAS
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GO:0071345 cellular response to cytokine stimulus IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes
GO:0050727 regulation of inflammatory response IBA
GO:0050728 negative regulation of inflammatory response IMP
GO:0050729 positive regulation of inflammatory response NAS
Immuno Process:  Inflammation
GO Annotations:  Associated to 4 GO processes, IEA only
GO:0050727 regulation of inflammatory response IBA
GO:0050728 negative regulation of inflammatory response IMP
GO:0050729 positive regulation of inflammatory response NAS
click arrow to show/hide IEA associations
GO:0036336 dendritic cell migration IEA
Physiological Functions Comments
Involved in inflammasome formation, bacterial control and inflammatory migration.
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Dermatitis
Description: Includes atopic, seborrhoeic, and contact dermatitis.
Disease Ontology: DOID:2723
Disease:  Familial cold autoinflammatory syndrome 2; FCAS2
Synonyms: NLRP12-associated hereditary periodic fever syndrome [Orphanet: ORPHA247868]
OMIM: 611762
Orphanet: ORPHA247868

Contributors

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How to cite this page

Bryant C, Monie TP. Pattern recognition receptors in GtoPdb v.2025.1. IUPHAR/BPS Guide to Pharmacology CITE. 2025; 2025(1). Available from: https://doi.org/10.2218/gtopdb/F302/2025.1.