Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	655	11p15.4	NLRP10	NLR family pyrin domain containing 10
Mouse	-	673	7 E3	Nlrp10	NLR family, pyrin domain containing 10
Rat	-	-	1q33	Nlrp10	NLR family

Previous and Unofficial Names

NALP10 | NOD8 | PAN5 | Pynod | NACHT, leucine rich repeat and PYD containing 10 | NLR family, pyrin domain containing 10 | CLR11.1 | NLR family

Database Links
Alphafold	Q86W26 (Hs), Q8CCN1 (Mm)
Ensembl Gene	ENSG00000182261 (Hs), ENSMUSG00000049709 (Mm), ENSRNOG00000015082 (Rn)
Entrez Gene	338322 (Hs), 244202 (Mm), 293426 (Rn)
Human Protein Atlas	ENSG00000182261 (Hs)
KEGG Gene	hsa:338322 (Hs), mmu:244202 (Mm), rno:293426 (Rn)
OMIM	609662 (Hs)
Pharos	Q86W26 (Hs)
UniProtKB	Q86W26 (Hs), Q8CCN1 (Mm)
Wikipedia	NLRP10 (Hs)

Immunopharmacology Comments

NLRP10 is an intracellular pattern recognition receptor (PRR) that has apoptotic and anti-inflammatory functions [1]. Unlike other other NOD-like receptors, NLRP10 is missing the characteristic leucine-rich repeat domain.

Immuno Process Associations

Immuno Process:  Inflammation GO Annotations:  Associated to 4 GO processes GO:0050727 regulation of inflammatory response IBA GO:0050729 positive regulation of inflammatory response ISS click arrow to show/hide IEA associations GO:0006954 inflammatory response IEA GO:0045087 innate immune response IEA

Immuno Process:  T cell (activation) GO Annotations:  Associated to 3 GO processes GO:0002827 positive regulation of T-helper 1 type immune response ISS GO:2000318 positive regulation of T-helper 17 type immune response ISS click arrow to show/hide IEA associations GO:0002250 adaptive immune response IEA

Immuno Process:  B cell (activation) GO Annotations:  Associated to 3 GO processes GO:0002827 positive regulation of T-helper 1 type immune response ISS GO:2000318 positive regulation of T-helper 17 type immune response ISS click arrow to show/hide IEA associations GO:0002250 adaptive immune response IEA

Immuno Process:  Immune regulation GO Annotations:  Associated to 4 GO processes GO:0002827 positive regulation of T-helper 1 type immune response ISS GO:0050727 regulation of inflammatory response IBA GO:0050729 positive regulation of inflammatory response ISS GO:2000318 positive regulation of T-helper 17 type immune response ISS

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 3 GO processes GO:0032730 positive regulation of interleukin-1 alpha production IMP GO:0032755 positive regulation of interleukin-6 production IMP GO:0032757 positive regulation of interleukin-8 production IMP

Physiological Functions Comments

Involved in antigen-presenting cell migration, T-Cell priming and NOD1 signalling enhancement.