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Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 892 | 11p15.5 | NLRP6 | NLR family pyrin domain containing 6 | |
Mouse | - | 869 | 7 F5 | Nlrp6 | NLR family, pyrin domain containing 6 | |
Rat | - | 881 | 1q41 | Nlrp6 | NLR family, pyrin domain containing 6 |
Database Links | |
Alphafold | P59044 (Hs), Q91WS2 (Mm), Q63035 (Rn) |
Ensembl Gene | ENSG00000174885 (Hs), ENSMUSG00000038745 (Mm), ENSRNOG00000045677 (Rn) |
Entrez Gene | 171389 (Hs), 101613 (Mm), 171390 (Rn) |
Human Protein Atlas | ENSG00000174885 (Hs) |
KEGG Gene | hsa:171389 (Hs), mmu:101613 (Mm), rno:171390 (Rn) |
OMIM | 609650 (Hs) |
Pharos | P59044 (Hs) |
UniProtKB | P59044 (Hs), Q91WS2 (Mm), Q63035 (Rn) |
Wikipedia | NLRP6 (Hs) |
Immunopharmacology Comments |
NLRP6 is an intracellular pattern recognition receptor (PRR). It is a member of the NACHT, LRR and PYD domains-containing protein (NALP) subfamily of PRRs. The presence of NALPs in inflammasomes underlies their involvement in regulating proinflammatory caspases (esp. caspase 1) and NF-κB. |
Immuno Process Associations | ||
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Physiological Functions Comments | |
Involved in negative regulation of inflammasome signalling, regulation of mucus secretion and host intestinal microbiota composition. |
Clinically-Relevant Mutations and Pathophysiology | ||||||||||||
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