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Target not currently curated in GtoImmuPdb

Target id: 1769

Nomenclature: NLRP2

Family: NOD-like receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1062 19q13.42 NLRP2 NLR family pyrin domain containing 2
Mouse - - 7 3.07 cM Nlrp2 NLR family, pyrin domain containing 2
Previous and Unofficial Names Click here for help
CLR19.9 | NALP2 | NBS1 | PAN1 | PYPAF2 | NACHT, leucine rich repeat and PYD containing 2 | XXbac-BPG230H20.8 | NLR family, pyrin domain containing 2 | NLR family
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IBA
GO:0032731 positive regulation of interleukin-1 beta production IDA
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes, IEA only
GO:0050727 regulation of inflammatory response IBA
click arrow to show/hide IEA associations
GO:0006954 inflammatory response IEA
GO:0045087 innate immune response IEA
Physiological Functions Comments
Involved in embryonic development.
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Beckwith-Wiedemann syndrome
Disease Ontology: DOID:5572
OMIM: 130650
Orphanet: ORPHA116
Disease:  Recurrent miscarriage


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