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NLRX1

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 1766

Nomenclature: NLRX1

Family: NOD-like receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 975 11q23.3 NLRX1 NLR family member X1
Mouse - 975 9 A5.2 Nlrx1 NLR family member X1
Rat - 973 8q22 Nlrx1 NLR family member X1
Previous and Unofficial Names Click here for help
CLR11.3 | NOD9 | NOD-like receptor X1 | NLR family member X1 | DLNB26 | NOD26 | NOD5
Database Links Click here for help
Alphafold
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia

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Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
amelenodor Small molecule or natural product Immunopharmacology Ligand Hs Activation 4.5 pKd 1
pKd 4.5 (Kd 3x10-5 M) [1]
Description: Dissociation constsnt determined by surface plasmon resonance
Immunopharmacology Comments
NLRX1 is an intracellular pattern recognition receptor that plays a role in host immunity to certain bacterial infections.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
Immuno Process:  Inflammation
Immuno Process:  Immune regulation
Immuno Process:  Cellular signalling
Physiological Functions Comments
Involved in negative regulation of inflammatory signalling.

References

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1. Bassaganya-Riera J, Leber A, Hontecillas R. (2020) 1,3,5-tris(6-methylpyridin-2-yloxy)benzene derivatives and related compounds as nlrx1 ligands for treating inflammatory diseases. Patent number: WO2020010132A1. Assignee: Landos Biopharma, Inc.. Priority date: 02/07/2019. Publication date: 09/01/2020.

Contributors

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