Top ▲
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 1866 | 16q13 | NLRC5 | NLR family CARD domain containing 5 | |
Mouse | - | 1915 | 8 C5 | Nlrc5 | NLR family, CARD domain containing 5 |
Database Links | |
Alphafold | Q86WI3 (Hs), C3VPR6 (Mm) |
CATH/Gene3D | 3.80.10.10 |
Ensembl Gene | ENSG00000140853 (Hs), ENSMUSG00000074151 (Mm) |
Entrez Gene | 84166 (Hs), 434341 (Mm) |
Human Protein Atlas | ENSG00000140853 (Hs) |
KEGG Gene | hsa:84166 (Hs), mmu:434341 (Mm) |
OMIM | 613537 (Hs) |
Pharos | Q86WI3 (Hs) |
UniProtKB | Q86WI3 (Hs), C3VPR6 (Mm) |
Wikipedia | NLRC5 (Hs) |
Immunopharmacology Comments |
NLRC5 is an intracellular pattern recognition receptor mediating an innate immune response to viral infection [4], likely by modulating the NF-κB and type I interferon signaling pathways [1-2]. |
Immuno Process Associations | ||
|
||
|
||
|
Immuno Disease Associations | ||||||||||
|
Physiological Functions Comments | |
Transactivator of class I major histocompatibility complex genes. |
1. Cui J, Zhu L, Xia X, Wang HY, Legras X, Hong J, Ji J, Shen P, Zheng S, Chen ZJ et al.. (2010) NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. Cell, 141 (3): 483-96. [PMID:20434986]
2. Kuenzel S, Till A, Winkler M, Häsler R, Lipinski S, Jung S, Grötzinger J, Fickenscher H, Schreiber S, Rosenstiel P. (2010) The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses. J Immunol, 184 (4): 1990-2000. [PMID:20061403]
3. Liu YR, Yan X, Yu HX, Yao Y, Wang JQ, Li XF, Chen RN, Xu QQ, Ma TT, Huang C et al.. (2017) NLRC5 promotes cell proliferation via regulating the NF-κB signaling pathway in Rheumatoid arthritis. Mol Immunol, 91: 24-34. [PMID:28865311]
4. Neerincx A, Lautz K, Menning M, Kremmer E, Zigrino P, Hösel M, Büning H, Schwarzenbacher R, Kufer TA. (2010) A role for the human nucleotide-binding domain, leucine-rich repeat-containing family member NLRC5 in antiviral responses. J Biol Chem, 285 (34): 26223-32. [PMID:20538593]