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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 1764

Nomenclature: NLRC3

Family: NOD-like receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1065 16p13.3 NLRC3 NLR family CARD domain containing 3
Mouse - 1064 16 A1 Nlrc3 NLR family, CARD domain containing 3
Rat - - 10 q12 Nlrc3 NLR family, CARD domain containing 3
Previous and Unofficial Names Click here for help
CLR16.2 | nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3 | NLR family, CARD domain containing 3 | Caterpiller 16.2 | NOD3 | NLR family
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
Immunopharmacology Comments
NLRC3 is an intracellular pattern recognition receptor of the innate immune system. It has been shown to directly interact with and inhibit the type I interferon response of the intracellular DNA sensor STING to cytosolic DNA, cyclic di-GMP (c-di-GMP), and DNA viruses [1-2].
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  T cell (activation)
Immuno Process:  Immune regulation
Immuno Process:  Cytokine production & signalling
Immuno Process:  Cellular signalling
Physiological Functions Comments
Negative regulation of inflammatory signalling.


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1. Mangan MS, Latz E. (2014) NLRC3 puts the brakes on STING. Immunity, 40 (3): 305-6. [PMID:24656040]

2. Zhang L, Mo J, Swanson KV, Wen H, Petrucelli A, Gregory SM, Zhang Z, Schneider M, Jiang Y, Fitzgerald KA et al.. (2014) NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING. Immunity, 40 (3): 329-41. [PMID:24560620]


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