Interleukin-12 receptor, β1 subunit | IL-12 receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Interleukin-12 receptor, β1 subunit

  Target has curated data in GtoImmuPdb

Target id: 1715

Nomenclature: Interleukin-12 receptor, β1 subunit

Family: IL-12 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Quaternary Structure: Complexes
Interleukin-12 receptor
Interleukin-23 receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 662 19p13.11 IL12RB1 interleukin 12 receptor subunit beta 1
Mouse 1 738 Il12rb1 interleukin 12 receptor, beta 1
Rat - - Il12rb1 interleukin 12 receptor subunit beta 1
Previous and Unofficial Names
CD212 | interleukin 12 receptor, beta 1 | interleukin 12 receptor
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Immunopharmacology Comments
This protein is a subunit of both the IL-12 and IL-23 cytokine receptors.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0043382 positive regulation of memory T cell differentiation ISS
GO:0071346 cellular response to interferon-gamma IDA
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 6 GO processes
GO:0001916 positive regulation of T cell mediated cytotoxicity ISS
GO:0002827 positive regulation of T-helper 1 type immune response IDA
GO:0042104 positive regulation of activated T cell proliferation IDA
GO:0043382 positive regulation of memory T cell differentiation ISS
GO:2000318 positive regulation of T-helper 17 type immune response ISS
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 4 GO processes
GO:0001916 positive regulation of T cell mediated cytotoxicity ISS
GO:0002827 positive regulation of T-helper 1 type immune response IDA
GO:2000318 positive regulation of T-helper 17 type immune response ISS
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 7 GO processes
GO:0001916 positive regulation of T cell mediated cytotoxicity ISS
GO:0002230 positive regulation of defense response to virus by host IDA
GO:0002827 positive regulation of T-helper 1 type immune response IDA
GO:0042104 positive regulation of activated T cell proliferation IDA
GO:0043382 positive regulation of memory T cell differentiation ISS
GO:2000318 positive regulation of T-helper 17 type immune response ISS
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS
Immuno Process:  Immune system development
GO Annotations:  Associated to 2 GO processes
GO:0043382 positive regulation of memory T cell differentiation ISS
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 6 GO processes
GO:0004896 cytokine receptor activity IBA
GO:0019221 cytokine-mediated signaling pathway TAS
GO:0032729 positive regulation of interferon-gamma production IDA
GO:0035722 interleukin-12-mediated signaling pathway TAS
GO:0038155 interleukin-23-mediated signaling pathway TAS
GO:0071346 cellular response to interferon-gamma IDA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 3 GO processes
GO:0042104 positive regulation of activated T cell proliferation IDA
GO:0043382 positive regulation of memory T cell differentiation ISS
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 3 GO processes
GO:0042104 positive regulation of activated T cell proliferation IDA
GO:0043382 positive regulation of memory T cell differentiation ISS
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS

How to cite this page

IL-12 receptor family: Interleukin-12 receptor, β1 subunit. Last modified on 22/03/2017. Accessed on 22/10/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1715.