Inositol 1,4,5-trisphosphate 3-kinases | Enzymes | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

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Inositol 1,4,5-trisphosphate 3-kinases

Inositol 1,4,5-trisphosphate 3-kinases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Inositol 1,4,5-trisphosphate 3-kinases (E.C. 2.7.1.127, ENSFM00250000001260) catalyse the generation of inositol 1,3,4,5-tetrakisphosphate (IP₄) from IP₃. IP₃ kinase activity is enhanced in the presence of calcium/calmodulin (CALM2, CALM3, CALM1, P62158) [1].

Enzymes

1449

Targets of relevance to immunopharmacology are highlighted in blue

IP₃ kinase A Show summary »« Hide summary

Target Id

1447

Nomenclature

IP₃ kinase A

Previous and unofficial names

Genes

ITPKA (Hs), Itpka (Mm), Itpka (Rn)

Ensembl ID

ENSG00000137825 (Hs), ENSMUSG00000027296 (Mm), ENSRNOG00000005284 (Rn)

UniProtKB AC

P23677 (Hs), Q8R071 (Mm), P17105 (Rn)

EC number

2.7.1.127

Inhibitors

GNF362 pIC₅₀ 7.7 [2]

IP₃ kinase B Show summary »« Hide summary More detailed page go icon to follow link

IP₃ kinase C Show summary »« Hide summary

Target Id

1449

Nomenclature

IP₃ kinase C

Previous and unofficial names

inositol 1,4,5-trisphosphate 3-kinase C | insP 3-kinase C | IP3KC | inositol 1

Genes

ITPKC (Hs), Itpkc (Mm), Itpkc (Rn)

Ensembl ID

ENSG00000086544 (Hs), ENSMUSG00000003752 (Mm), ENSRNOG00000013945 (Rn)

UniProtKB AC

Q96DU7 (Hs), Q7TS72 (Mm), Q80ZG2 (Rn)

EC number

2.7.1.127

Inhibitors

GNF362 pIC₅₀ 7.7 [2]

References

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How to cite this family page

Database page citation:

Inositol 1,4,5-trisphosphate 3-kinases. Accessed on 02/04/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=280.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Enzymes. Br J Pharmacol. 182: S307-S403.