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Inositol 1,4,5-trisphosphate 3-kinases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Inositol 1,4,5-trisphosphate 3-kinases (E.C. 2.7.1.127, ENSFM00250000001260) catalyse the generation of inositol 1,3,4,5-tetrakisphosphate (IP4) from IP3. IP3 kinase activity is enhanced in the presence of calcium/calmodulin (CALM2, CALM3, CALM1, P62158) [1].

Enzymes

1447
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Targets of relevance to immunopharmacology are highlighted in blue

IP3 kinase A Show summary »

Target Id 1447
Nomenclature IP3 kinase A
Previous and unofficial names IP3KA | inositol 1,4,5-trisphosphate 3-kinase A | insP 3-kinase A | IP3 3-kinase A | IP3-kinase A | inositol 1
Genes ITPKA (Hs), Itpka (Mm), Itpka (Rn)
Ensembl ID ENSG00000137825 (Hs), ENSMUSG00000027296 (Mm), ENSRNOG00000005284 (Rn)
UniProtKB AC P23677 (Hs), Q8R071 (Mm), P17105 (Rn)
EC number
2.7.1.127
Inhibitors
GNF362 pIC50 7.7 [2]

IP3 kinase B Show summary » More detailed page go icon to follow link

IP3 kinase C Show summary »

References

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How to cite this family page

Database page citation:

Inositol 1,4,5-trisphosphate 3-kinases. Accessed on 02/04/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=280.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Enzymes. Br J Pharmacol. 182: S307-S403.