PLD1 | Phosphatidylcholine-specific phospholipase D | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 1433

Nomenclature: PLD1

Family: Phosphatidylcholine-specific phospholipase D

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - PLD1 phospholipase D1
Mouse - - Pld1 phospholipase D1
Rat - - Pld1 phospholipase D1
Previous and Unofficial Names
Choline phosphatase 1 | phosphatidylcholine-hydrolyzing phospholipase D1 | phospholipase D1 | Pld1a | Pld1b | phospholipase D1, phosphatidylcholine-specific
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
Enzyme Reaction
EC Number:
Endogenous activators (Human)
ADP-ribosylation factor 1 (ARF1, P84077), PIP2, RhoA, PKC evoked phosphorylation, RalA  [1-2]
Endogenous inhibitor (Human)
Gβγ  [3]

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
FIPI Hs Inhibition 8.0 pIC50 4
pIC50 8.0 (IC50 9.5x10-9 M) [4]
compound 69 [PMID: 19136975] Hs Inhibition 7.3 pIC50 4
pIC50 7.3 (IC50 4.6x10-8 M) [4]
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS


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1. Hammond SM, Jenco JM, Nakashima S, Cadwallader K, Gu Q, Cook S, Nozawa Y, Prestwich GD, Frohman MA, Morris AJ. (1997) Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-alpha. J. Biol. Chem., 272 (6): 3860-8. [PMID:9013646]

2. Luo JQ, Liu X, Hammond SM, Colley WC, Feig LA, Frohman MA, Morris AJ, Foster DA. (1997) RalA interacts directly with the Arf-responsive, PIP2-dependent phospholipase D1. Biochem. Biophys. Res. Commun., 235 (3): 854-9. [PMID:9207251]

3. Preininger AM, Henage LG, Oldham WM, Yoon EJ, Hamm HE, Brown HA. (2006) Direct modulation of phospholipase D activity by Gbetagamma. Mol. Pharmacol., 70 (1): 311-8. [PMID:16638972]

4. Scott SA, Selvy PE, Buck JR, Cho HP, Criswell TL, Thomas AL, Armstrong MD, Arteaga CL, Lindsley CW, Brown HA. (2009) Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat. Chem. Biol., 5 (2): 108-17. [PMID:19136975]

How to cite this page

Phosphatidylcholine-specific phospholipase D: PLD1. Last modified on 10/07/2018. Accessed on 05/07/2020. IUPHAR/BPS Guide to PHARMACOLOGY,