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Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 1290 | 20q12 | PLCG1 | phospholipase C gamma 1 | |
Mouse | - | 1302 | 2 80.97 cM | Plcg1 | phospholipase C, gamma 1 | |
Rat | - | 1290 | 3q42 | Plcg1 | phospholipase C, gamma 1 |
Database Links | |
Alphafold | P19174 (Hs), Q62077 (Mm), P10686 (Rn) |
BRENDA | 3.1.4.11 |
CATH/Gene3D | 2.30.29.30, 2.60.40.150, 3.20.20.190, 3.30.505.10 |
ChEMBL Target | CHEMBL3964 (Hs), CHEMBL5188 (Rn) |
Ensembl Gene | ENSG00000124181 (Hs), ENSMUSG00000016933 (Mm), ENSRNOG00000051490 (Rn) |
Entrez Gene | 5335 (Hs), 18803 (Mm), 25738 (Rn) |
Human Protein Atlas | ENSG00000124181 (Hs) |
KEGG Enzyme | 3.1.4.11 |
KEGG Gene | hsa:5335 (Hs), mmu:18803 (Mm), rno:25738 (Rn) |
OMIM | 172420 (Hs) |
Pharos | P19174 (Hs) |
RefSeq Nucleotide | NM_002660 (Hs) |
RefSeq Protein | NP_002651 (Hs) |
UniProtKB | P19174 (Hs), Q62077 (Mm), P10686 (Rn) |
Wikipedia | PLCG1 (Hs) |
Enzyme Reaction | ||||
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Cofactors | ||||||||
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Endogenous activators (Human) |
PIP3 [1] |
Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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Immunopharmacology Comments |
Two structurally similar isoforms of PLCγ are expressed by mast cells (PLCγ1 and PLCγ2). Both are important enzymes in the integrated signalling pathways leading to mast cell activation [2,4], although PLCγ1 may be the predominant isoform active in human mast cells [5]. |
Cell Type Associations | ||||
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1. Bae YS, Cantley LG, Chen CS, Kim SR, Kwon KS, Rhee SG. (1998) Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem, 273 (8): 4465-9. [PMID:9468499]
2. Gilfillan AM, Tkaczyk C. (2006) Integrated signalling pathways for mast-cell activation. Nat Rev Immunol, 6 (3): 218-30. [PMID:16470226]
3. Lee JS, Kim J, Kim BY, Lee HS, Ahn JS, Chang YS. (2000) Inhibition of phospholipase cgamma1 and cancer cell proliferation by triterpene esters from Uncaria rhynchophylla. J Nat Prod, 63 (6): 753-6. [PMID:10869194]
4. Saitoh S, Arudchandran R, Manetz TS, Zhang W, Sommers CL, Love PE, Rivera J, Samelson LE. (2000) LAT is essential for Fc(epsilon)RI-mediated mast cell activation. Immunity, 12 (5): 525-35. [PMID:10843385]
5. Tkaczyk C, Beaven MA, Brachman SM, Metcalfe DD, Gilfillan AM. (2003) The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase. J Biol Chem, 278 (48): 48474-84. [PMID:13129935]
Phosphoinositide-specific phospholipase C: PLCγ1. Last modified on 10/07/2018. Accessed on 04/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1407.