<i>GPR160</i> | Class A Orphans | IUPHAR Guide to IMMUNOPHARMACOLOGY

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GPR160

Target not currently curated in GtoImmuPdb

Target id: 140

Nomenclature: GPR160

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 338 3q26.2-q27 GPR160 G protein-coupled receptor 160
Mouse 7 336 3 B Gpr160 G protein-coupled receptor 160
Rat 7 336 2q24 Gpr160 G protein-coupled receptor 160
Previous and Unofficial Names
GPCR1 | GPCR150
Database Links
Specialist databases
GPCRDB gp160_human (Hs), gp160_mouse (Mm), gp160_rat (Rn)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays
miR-125b negatively regulates GPR160 expression in lymphoblastoid cell lines
Species:  Human
Tissue:  Lymphoblastoid cell line
Response measured:  Decreased expression
References:  2
Clinically-Relevant Mutations and Pathophysiology
Disease:  Metastatic melanoma
Disease Ontology: DOID:4358
Comments: 
References:  4
Disease:  Nasopharyngeal carcinoma
OMIM: 607107
Comments: 
References:  3
Disease:  Prostate cancer
Disease Ontology: DOID:10283
OMIM: 176807
Comments: 
References:  1,3
Biologically Significant Variants
Type:  Naturally occurring SNP
Species:  Human
Amino acid change:  V65I
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  Q14E
Global MAF (%):  1
Subpopulation MAF (%):  AFR: 4
Minor allele count:  G=0.010/21
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 
Validation:  1000 Genomes, Frequency

References

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1. Dijkman R, van Doorn R, Szuhai K, Willemze R, Vermeer MH, Tensen CP. (2007) Gene-expression profiling and array-based CGH classify CD4+CD56+ hematodermic neoplasm and cutaneous myelomonocytic leukemia as distinct disease entities. Blood, 109 (4): 1720-7. [PMID:17068154]

2. Lee JE, Hong EJ, Nam HY, Kim JW, Han BG, Jeon JP. (2011) MicroRNA signatures associated with immortalization of EBV-transformed lymphoblastoid cell lines and their clinical traits. Cell Prolif., 44 (1): 59-66. [PMID:21199010]

3. Mudipalli A, Owen RD, Preston RJ. (2005) The effect of arsenicals on ultraviolet-radiation-induced growth arrest and related signaling events in human keratinocytes. Int. J. Oncol., 27 (3): 769-78. [PMID:16077927]

4. Qin Y, Verdegaal EM, Siderius M, Bebelman JP, Smit MJ, Leurs R, Willemze R, Tensen CP, Osanto S. (2011) Quantitative expression profiling of G-protein-coupled receptors (GPCRs) in metastatic melanoma: the constitutively active orphan GPCR GPR18 as novel drug target. Pigment Cell Melanoma Res, 24 (1): 207-18. [PMID:20880198]

Contributors

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