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GPR160

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Target not currently curated in GtoImmuPdb

Target id: 140

Nomenclature: GPR160

Family: Class A Orphans

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 338 3q26.2 GPR160 G protein-coupled receptor 160
Mouse 7 336 3 A3 Gpr160 G protein-coupled receptor 160
Rat 7 336 2q24 Gpr160 G protein-coupled receptor 160
Previous and Unofficial Names Click here for help
GPCR1 | GPCR150
Database Links Click here for help
Specialist databases
GPCRdb gp160_human (Hs), gp160_mouse (Mm), gp160_rat (Rn)
Other databases
Alphafold Q9UJ42 (Hs), Q3U3F9 (Mm), Q66H29 (Rn)
ChEMBL Target CHEMBL1777664 (Hs)
Ensembl Gene ENSG00000173890 (Hs), ENSMUSG00000037661 (Mm), ENSRNOG00000009487 (Rn)
Entrez Gene 26996 (Hs), 71862 (Mm), 499588 (Rn)
Human Protein Atlas ENSG00000173890 (Hs)
KEGG Gene hsa:26996 (Hs), mmu:71862 (Mm), rno:499588 (Rn)
Pharos Q9UJ42 (Hs)
RefSeq Nucleotide NM_014373 (Hs), NM_001134385 (Mm), NM_001025147 (Rn)
RefSeq Protein NP_055188 (Hs), NP_001127857 (Mm), NP_001020318 (Rn)
UniProtKB Q9UJ42 (Hs), Q3U3F9 (Mm), Q66H29 (Rn)
Wikipedia GPR160 (Hs)
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays Click here for help
miR-125b negatively regulates GPR160 expression in lymphoblastoid cell lines
Species:  Human
Tissue:  Lymphoblastoid cell line
Response measured:  Decreased expression
References:  2
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Metastatic melanoma
Disease Ontology: DOID:4358
Comments:  Receptor overexpression observed in melanoma metastases.
References:  4
Disease:  Nasopharyngeal carcinoma
OMIM: 607107
Comments:  Increased gene expression seen in nasopharangeal carcinoma identified by combined microarray and FISH analysis.
References:  3
Disease:  Prostate cancer
Disease Ontology: DOID:10283
OMIM: 176807
Comments:  Gene associated with prostate cancer identified by microarray analysis.
References:  1,3
Biologically Significant Variants Click here for help
Type:  Naturally occurring SNP
Species:  Human
Amino acid change:  V65I
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession:  rs61745703
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  Q14E
Global MAF (%):  1
Subpopulation MAF (%):  AFR: 4
Minor allele count:  G=0.010/21
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession:  rs73030619
Validation:  1000 Genomes, Frequency

References

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1. Dijkman R, van Doorn R, Szuhai K, Willemze R, Vermeer MH, Tensen CP. (2007) Gene-expression profiling and array-based CGH classify CD4+CD56+ hematodermic neoplasm and cutaneous myelomonocytic leukemia as distinct disease entities. Blood, 109 (4): 1720-7. [PMID:17068154]

2. Lee JE, Hong EJ, Nam HY, Kim JW, Han BG, Jeon JP. (2011) MicroRNA signatures associated with immortalization of EBV-transformed lymphoblastoid cell lines and their clinical traits. Cell Prolif, 44 (1): 59-66. [PMID:21199010]

3. Mudipalli A, Owen RD, Preston RJ. (2005) The effect of arsenicals on ultraviolet-radiation-induced growth arrest and related signaling events in human keratinocytes. Int J Oncol, 27 (3): 769-78. [PMID:16077927]

4. Qin Y, Verdegaal EM, Siderius M, Bebelman JP, Smit MJ, Leurs R, Willemze R, Tensen CP, Osanto S. (2011) Quantitative expression profiling of G-protein-coupled receptors (GPCRs) in metastatic melanoma: the constitutively active orphan GPCR GPR18 as novel drug target. Pigment Cell Melanoma Res, 24 (1): 207-18. [PMID:20880198]

Contributors

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