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CYP2B6

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Target not currently curated in GtoImmuPdb

Target id: 1324

Nomenclature: CYP2B6

Family: CYP2 family: drug metabolising subset

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 491 19q13.2 CYP2B6 cytochrome P450 family 2 subfamily B member 6
Previous and Unofficial Names Click here for help
cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6 | 1,4-cineole 2-exo-monooxygenase | cytochrome P450, family 2, subfamily B, polypeptide 6
Database Links Click here for help
Alphafold P20813 (Hs)
BRENDA 1.14.14.1
ChEMBL Target CHEMBL4729 (Hs)
Ensembl Gene ENSG00000197408 (Hs)
Entrez Gene 1555 (Hs)
Human Protein Atlas ENSG00000197408 (Hs)
KEGG Enzyme 1.14.14.1
KEGG Gene hsa:1555 (Hs)
OMIM 123930 (Hs)
Pharos P20813 (Hs)
UniProtKB P20813 (Hs)
Wikipedia CYP2B6 (Hs)
Enzyme Reaction Click here for help
EC Number: 1.14.14.1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
thiotepa Small molecule or natural product Approved drug Hs Inhibition 5.3 pKi 3
⤷ pKi 5.3 (Ki 4.8x10-6 M) [3]
ticlopidine Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibition 6.7 pIC50 2
⤷ pIC50 6.7 (IC50 2x10-7 M) [2]
sibutramine Small molecule or natural product Approved drug Click here for species-specific activity table Hs Inhibition 5.8 pIC50 1
⤷ pIC50 5.8 (IC50 1.61x10-6 M) [1]

References

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1. Bae SH, Kwon MJ, Choi EJ, Zheng YF, Yoon KD, Liu KH, Bae SK. (2013) Potent inhibition of cytochrome P450 2B6 by sibutramine in human liver microsomes. Chem Biol Interact, 205 (1): 11-9. [PMID:23777987]

2. Fontana E, Dansette PM, Poli SM. (2005) Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Curr Drug Metab, 6 (5): 413-54. [PMID:16248836]

3. Walsky RL, Obach RS. (2007) A comparison of 2-phenyl-2-(1-piperidinyl)propane (ppp), 1,1',1''-phosphinothioylidynetrisaziridine (thioTEPA), clopidogrel, and ticlopidine as selective inactivators of human cytochrome P450 2B6. Drug Metab Dispos, 35 (11): 2053-9. [PMID:17682072]

Contributors

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