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CYP1A2

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Target not currently curated in GtoImmuPdb

Target id: 1319

Nomenclature: CYP1A2

Family: CYP1 family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 516 15q24.1 CYP1A2 cytochrome P450 family 1 subfamily A member 2
Mouse - 513 9 31.3 cM Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2
Rat - 513 8q24 Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2
Previous and Unofficial Names Click here for help
cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2 | cytochrome P450 1A2 | Cytochrome P450 subfamily I (aromatic compound-inducible) member A2 (Q42 form d) | cytochrome P450, family 1, subfamily A, polypeptide 2 | cytochrome P450, family 1, subfamily a, polypeptide 2 | cytochrome P450
Database Links Click here for help
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
Pharos
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 1.14.1.1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
5H78PF Small molecule or natural product Hs Inhibition 7.8 pIC50 1
pIC50 7.8 (IC50 1.4x10-8 M) [1]
5H3'FPE Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.4 pIC50 1
pIC50 6.4 (IC50 4.2x10-7 M) [1]

References

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1. Liu J, Taylor SF, Dupart PS, Arnold CL, Sridhar J, Jiang Q, Wang Y, Skripnikova EV, Zhao M, Foroozesh M. (2013) Pyranoflavones: a group of small-molecule probes for exploring the active site cavities of cytochrome P450 enzymes 1A1, 1A2, and 1B1. J Med Chem, 56 (10): 4082-92. [PMID:23600958]

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