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Gene and Protein Information ![]() |
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Species | TM | P Loops | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 4 | 2 | 307 | 11q13.1 | KCNK7 | potassium two pore domain channel subfamily K member 7 | 2 |
Mouse | 4 | 2 | 307 | 19 A | Kcnk7 | potassium channel, subfamily K, member 7 | 1-2 |
Rat | 6 | 2 | 316 | 1q43 | Kcnk7 | potassium two pore domain channel subfamily K member 7 |
Previous and Unofficial Names ![]() |
kcnk8 | Knot | Mlk3 | potassium channel, subfamily K, member 7 | potassium channel, two pore domain subfamily K, member 7 | potassium channel |
Database Links ![]() |
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Alphafold | Q9Y2U2 (Hs), Q9Z2T1 (Mm), D4A806 (Rn) |
Ensembl Gene | ENSG00000173338 (Hs), ENSMUSG00000024936 (Mm), ENSRNOG00000020784 (Rn) |
Entrez Gene | 10089 (Hs), 16530 (Mm), 499303 (Rn) |
Human Protein Atlas | ENSG00000173338 (Hs) |
KEGG Gene | hsa:10089 (Hs), mmu:16530 (Mm), rno:499303 (Rn) |
OMIM | 603940 (Hs) |
Pharos | Q9Y2U2 (Hs) |
RefSeq Nucleotide | NM_033347 (Hs), NM_010609 (Mm) |
RefSeq Protein | NP_203133 (Hs), NP_034739 (Mm) |
UniProtKB | Q9Y2U2 (Hs), Q9Z2T1 (Mm), D4A806 (Rn) |
Wikipedia | KCNK7 (Hs) |
Functional Characteristics ![]() |
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Unknown |
Phenotypes, Alleles and Disease Models ![]() |
Mouse data from MGI | ||||||||||||
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General Comments |
The product of this gene has not yet been shown to form a functional channel. Five splice variants have been identified in human. The mouse isolate was cited as kcnk6 and then kcnk8 but is now called K2P7 due to its homology and syntenic location to human KCNK7 [1]. |
1. Bockenhauer D, Nimmakayalu MA, Ward DC, Goldstein SA, Gallagher PG. (2000) Genomic organization and chromosomal localization of the murine 2 P domain potassium channel gene Kcnk8: conservation of gene structure in 2 P domain potassium channels. Gene, 261 (2): 365-72. [PMID:11167025]
2. Salinas M, Reyes R, Lesage F, Fosset M, Heurteaux C, Romey G, Lazdunski M. (1999) Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure. J Biol Chem, 274 (17): 11751-60. [PMID:10206991]