Gene and Protein Information
class A G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	333	7p22.3	GPR146	G protein-coupled receptor 146
Mouse	7	333	5 G2	Gpr146	G protein-coupled receptor 146
Rat	7	333	12q11	Gpr146	G protein-coupled receptor 146

Previous and Unofficial Names

AXOR120 | G-protein coupled receptor PGR8

Database Links
Specialist databases
GPCRdb	gp146_human (Hs)
Other databases
Alphafold	Q96CH1 (Hs), Q99LE2 (Mm)
ChEMBL Target	CHEMBL4523904 (Hs)
Ensembl Gene	ENSG00000164849 (Hs), ENSMUSG00000044197 (Mm), ENSRNOG00000001288 (Rn)
Entrez Gene	115330 (Hs), 80290 (Mm), 498153 (Rn)
Human Protein Atlas	ENSG00000164849 (Hs)
KEGG Gene	hsa:115330 (Hs), mmu:80290 (Mm), rno:498153 (Rn)
Pharos	Q96CH1 (Hs)
RefSeq Nucleotide	NM_138445 (Hs), NM_030258 (Mm), NM_001109062 (Rn)
RefSeq Protein	NP_612454 (Hs), NP_084534 (Mm), NP_001102532 (Rn)
UniProtKB	Q96CH1 (Hs), Q99LE2 (Mm)
Wikipedia	GPR146 (Hs)

Agonist Comments

Yosten et al. demonstrated inhibition of proinsulin C-peptide-induced stimulation of cFos expression folllowing knockdown of GPR146 in KATOIII cells, suggesting proinsulin C-peptide as an endogenous ligand of the receptor [1].

Expression Datasets
Show »« Hide Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website] There should be a chart of expression data here, you may need to enable JavaScript!

Biologically Significant Variants
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  G11E SNP accession:  rs11761941
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  V266M Comment on frequency:  Low frequency (<10% in all tested populations) SNP accession:  rs55677825