Gene and Protein Information
class A G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	358	3q25.1	GPR87	G protein-coupled receptor 87	4
Mouse	7	358	3 D	Gpr87	G protein-coupled receptor 87
Rat	7	358	2q31	Gpr87	G protein-coupled receptor 87

Previous and Unofficial Names

FKSG78 | GPR95

Database Links
Specialist databases
GPCRdb	gpr87_human (Hs), gpr87_mouse (Mm)
Other databases
Alphafold	Q9BY21 (Hs), Q99MT7 (Mm)
ChEMBL Target	CHEMBL4523915 (Hs)
Ensembl Gene	ENSG00000138271 (Hs), ENSMUSG00000051431 (Mm), ENSRNOG00000013894 (Rn)
Entrez Gene	53836 (Hs), 84111 (Mm), 310443 (Rn)
Human Protein Atlas	ENSG00000138271 (Hs)
KEGG Gene	hsa:53836 (Hs), mmu:84111 (Mm), rno:310443 (Rn)
OMIM	606379 (Hs)
Pharos	Q9BY21 (Hs)
RefSeq Nucleotide	NM_023915 (Hs), NM_032399 (Mm), NM_001107677 (Rn)
RefSeq Protein	NP_076404 (Hs), NP_115775 (Mm), NP_001101147 (Rn)
UniProtKB	Q9BY21 (Hs), Q99MT7 (Mm)
Wikipedia	GPR87 (Hs)

Natural/Endogenous Ligands
LPA
Comments: Proposed ligand, single publication

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference LPA Hs Agonist 7.4 pEC50 2-3 ⤷ pEC50 7.4 [2-3]

Antagonists
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference Ki16425 Hs Antagonist - - 3 ⤷ [3] dioctanoylglycerol pyrophosphate Hs Antagonist - - 3 ⤷ [3]
Antagonist Comments
The LPA-induced [Ca2+]i increase is blocked by the LPA receptor antagonist, Ki16425 and DGPP suggesting that these may be antagonists [3].

Tissue Distribution
Squamous cell carcinomas Expression level:  High Species:  Human Technique:  Transcription profiling, siRNA analyses, Immunoblotting, Immunohistochemistry References:  1

Expression Datasets
Show »« Hide Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website] There should be a chart of expression data here, you may need to enable JavaScript!

Biologically Significant Variants
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  T205M Global MAF (%):  <1 Subpopulation MAF (%):  AFR: 1 Minor allele count:  A=0.002/4 Comment on frequency:  Low frequency (<10% in all tested populations) SNP accession:  VAR_055921, rs35521104 Validation:  1000 Genomes, Frequency, Multiple observations
Type:  Naturally occurring SNP Species:  Human Amino acid change:  V260G SNP accession:  rs76418398
Type:  Naturally occurring SNP Species:  Human Amino acid change:  S244X Comment on frequency:  Low frequency (<10% of all tested populations) SNP accession:  rs79475431
Type:  Naturally occurring SNP Species:  Human Amino acid change:  V171G Comment on frequency:  Low frequency (<10% of all tested populations) SNP accession:  rs79977940