<i>GPR27</i> | Class A Orphans with no pharmacology | IUPHAR Guide to IMMUNOPHARMACOLOGY

GPR27

Target not currently curated in GtoImmuPdb

Target id: 97

Nomenclature: GPR27

Family: Class A Orphans with no pharmacology

Gene and Protein Information
class A G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	375	3p13	GPR27	G protein-coupled receptor 27	3-4
Mouse	7	379	6 D3	Gpr27	G protein-coupled receptor 27
Rat	7	377	4q34	Gpr27	G protein-coupled receptor 27

Previous and Unofficial Names
super conserved receptor expressed in brain 1 \| SREB1

Database Links
Specialist databases
GPCRdb	gpr27_human (Hs), gpr27_mouse (Mm), gpr27_rat (Rn)
Other databases
Alphafold	Q9NS67 (Hs), O54897 (Mm), Q9JJH3 (Rn)
ChEMBL Target	CHEMBL4523923 (Hs)
Ensembl Gene	ENSG00000170837 (Hs), ENSMUSG00000072875 (Mm), ENSRNOG00000010880 (Rn)
Entrez Gene	2850 (Hs), 14761 (Mm), 65275 (Rn)
Human Protein Atlas	ENSG00000170837 (Hs)
KEGG Gene	hsa:2850 (Hs), mmu:14761 (Mm), rno:65275 (Rn)
OMIM	605187 (Hs)
Pharos	Q9NS67 (Hs)
RefSeq Nucleotide	NM_018971 (Hs), NM_008158 (Mm), NM_023099 (Rn)
RefSeq Protein	NP_061844 (Hs), NP_032184 (Mm), NP_075587 (Rn)
UniProtKB	Q9NS67 (Hs), O54897 (Mm), Q9JJH3 (Rn)
Wikipedia	GPR27 (Hs)

Primary Transduction Mechanisms
Transducer	Effector/Response
G_q/G₁₁ family	Phospholipase C stimulation
Comments: Alteration of gene expression affects stimulation of IP₃ [1]
References:

Tissue Distribution

Brain (caudate nucleus, putamen, hippocampus, subthalamic nucleus), ovary, testis, heart, prostate, pancreas, peripheral leukocytes

Species:	Human
Technique:	Northern Blot
References:	3

Cerebral cortex (piriform cortex, anterior cingulate, frontoparietal, somatosensory areas); caudate putamen, nucleus accumbens; hypothalamic nuclei (suprachiasmatic, supraoptic, ventromedial, paraventricular, arcuate)

Species:	Rat
Technique:	in situ hybridisation
References:	4

Whole brain, hippocampus, striatum, frontal cortex, thalamus, pons, hypothalamus

Species:	Rat
Technique:	Northern Blot
References:	4

Tissue Distribution Comments

GPR27 has been detected at higher levels in fetal brains than in adult brains, suggesting a role in neural plasticity. The receptor is highly conserved amongst mammals, with expression seen in grey matter areas of the monkey brain (hippocampal dentate gyrus and supraoptic nucleus of the hypothalamus) as demonstrated by in situ hybridisation [2].

Expression Datasets

Show »« Hide

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

There should be a chart of expression data here, you may need to enable JavaScript!

Physiological Consequences of Altering Gene Expression

Overexpression of Gpr27 increases inositol trisphosphate levels with no effect on cAMP

Species:	Mouse
Tissue:	MIN6 cells
Technique:	Gene overexpression
References:	1

Knockdown of Gpr27 reduces endogenous mouse insulin promotor activity and glucose stimulated insulin secretion

Species:	Mouse
Tissue:	Pancreatic β cells
Technique:	RNA interference
References:	1

Clinically-Relevant Mutations and Pathophysiology Comments
GPR27 mapped to a 15Mb constitutional de novo interstitial deletion of chromosome 3 shown to cause developmental delay and congenital anomalies. Deletion is also seen along with FOXP1, EIF4E3 and PROK2 resulting in speech delay, contractures, hypertonia and blepharophimosis, although the physiological role (if any) of GPR27 is unknown [5-6].

Clinically-Relevant Mutations and Pathophysiology Comments

GPR27 mapped to a 15Mb constitutional de novo interstitial deletion of chromosome 3 shown to cause developmental delay and congenital anomalies. Deletion is also seen along with FOXP1, EIF4E3 and PROK2 resulting in speech delay, contractures, hypertonia and blepharophimosis, although the physiological role (if any) of GPR27 is unknown [5-6].

References

Show »« Hide

1. Ku GM, Pappalardo Z, Luo CC, German MS, McManus MT. (2012) An siRNA screen in pancreatic beta cells reveals a role for Gpr27 in insulin production. PLoS Genet, 8 (1): e1002449. [PMID:22253604]

2. Matsumoto M, Beltaifa S, Weickert CS, Herman MM, Hyde TM, Saunders RC, Lipska BK, Weinberger DR, Kleinman JE. (2005) A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain. Brain Res Mol Brain Res, 138 (1): 58-69. [PMID:15893849]

3. Matsumoto M, Saito T, Takasaki J, Kamohara M, Sugimoto T, Kobayashi M, Tadokoro M, Matsumoto S, Ohishi T, Furuichi K. (2000) An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. Biochem Biophys Res Commun, 272 (2): 576-82. [PMID:10833454]

4. O'Dowd BF, Nguyen T, Marchese A, Cheng R, Lynch KR, Heng HH, Kolakowski Jr LF, George SR. (1998) Discovery of three novel G-protein-coupled receptor genes. Genomics, 47 (2): 310-3. [PMID:9479505]

5. Pariani MJ, Spencer A, Graham JM, Rimoin DL. (2009) A 785kb deletion of 3p14.1p13, including the FOXP1 gene, associated with speech delay, contractures, hypertonia and blepharophimosis. Eur J Med Genet, 52 (2-3): 123-7. [PMID:19332160]

6. Petek E, Windpassinger C, Simma B, Mueller T, Wagner K, Kroisel PM. (2003) Molecular characterisation of a 15 Mb constitutional de novo interstitial deletion of chromosome 3p in a boy with developmental delay and congenital anomalies. J Hum Genet, 48 (6): 283-7. [PMID:12836054]

How to cite this page

Select citation format:

GPR27

Contents:

References

How to cite this page