Gene and Protein Information
class A G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	609	1p36.31	GPR153	G protein-coupled receptor 153
Mouse	7	631	4 E2	Gpr153	G protein-coupled receptor 153
Rat	6	569	5q36	Gpr153	G protein-coupled receptor 153

Previous and Unofficial Names

PGR1

Database Links
Specialist databases
GPCRdb	gp153_human (Hs), gp153_mouse (Mm)
Other databases
Alphafold	Q6NV75 (Hs), Q8K0Z9 (Mm), D4ABT6 (Rn)
ChEMBL Target	CHEMBL4523876 (Hs)
Ensembl Gene	ENSG00000158292 (Hs), ENSMUSG00000042804 (Mm), ENSRNOG00000010718 (Rn)
Entrez Gene	387509 (Hs), 100129 (Mm), 619550 (Rn)
Human Protein Atlas	ENSG00000158292 (Hs)
KEGG Gene	hsa:387509 (Hs), mmu:100129 (Mm), rno:619550 (Rn)
OMIM	614269 (Hs)
Pharos	Q6NV75 (Hs)
RefSeq Nucleotide	NM_207370 (Hs), NM_178406 (Mm), NM_001034855 (Rn)
RefSeq Protein	NP_997253 (Hs), NP_848493 (Mm), NP_001030027 (Rn)
UniProtKB	Q6NV75 (Hs), Q8K0Z9 (Mm), D4ABT6 (Rn)
Wikipedia	GPR153 (Hs)

Tissue Distribution
High expression in thalamus, cerebral cortex and striatum. In the hypothalamus, expression was restricted to the arcuate and paraventricular nuclei. Moderate to high expression was detected in certain amygdaloidal regions such as posterolateral cortical amygdaloidal area, anterior cortical amygdaloidal area, anterior cortical amygdaloidal area, medial amygdaloidal area and basomedial amygdaloidal nucleus. Species:  Mouse Technique:  in situ hybridization References:  1
Brainstem, cerebellum, prefrontal cortex, cortex, hypothalamus, hippocampus, eye, spinal cord, adrenal gland, skeletal muscle, heart, kidney, liver, lungs, spleen, thymus, stomach, uterus, testicle, intestine, blood, skin, choroid plexus Species:  Rat Technique:  RT-PCR References:  1
Tissue Distribution Comments
Expression of GPR153 was not detected in the rat hippocampus, brain stem, ventromedial and lateral hypothalamus or basolateral amygdaloidal nucleus examined by in situ hybridization [1]. GPR153 expression pattern was found to be specific to the grey matter but lacking in the white matter [1].

Expression Datasets
Show »« Hide Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website] There should be a chart of expression data here, you may need to enable JavaScript!

Physiological Consequences of Altering Gene Expression
In the elevated plus maze test, Gpr153 knockdown rats showed a significant reduction in the time spent in the central square which is a probable measure of decision making. Species:  Rat Tissue:  Cerebral ventricle Technique:  Gene knockdown by Gpr153 antisense oligodeooxynucleotide References:  1

Biologically Significant Variants
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  R73H Global MAF (%):  2 Subpopulation MAF (%):  AFR|AMR: 7|1 Minor allele count:  T=0.018/39 Comment on frequency:  Low frequency (<10% in all tested populations) SNP accession:  rs61741782 Validation:  1000 Genomes, Frequency
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  G347D Global MAF (%):  2 Subpopulation MAF (%):  AFR|AMR: 7|1 Minor allele count:  T=0.018/39 Comment on frequency:  Low frequency (<10% in all tested populations) SNP accession:  rs111970052 Validation:  1000 Genomes, Frequency
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  R209H Global MAF (%):  31 Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 31|23|41|28 Minor allele count:  C=0.312/682 SNP accession:  rs12735670 Validation:  1000 Genomes, Frequency
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  V402M Global MAF (%):  5 Subpopulation MAF (%):  ASN: 19 Minor allele count:  T=0.051/112 SNP accession:  rs78132938 Validation:  1000 Genomes, Frequency
Type:  Naturally occurring SNP Species:  Human Amino acid change:  T102P Comment on frequency:  Low frequency (<10% in all tested populations) SNP accession:  rs78547048

General Comments
GPR153 is a cerebellar target of the Gli1 transcription factor, which is involved in the maintenance and proliferation of grabule neuron precursor cells in the cerebellum [1].