Gene and Protein Information
class A G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	368	3p21.2	GPR62	G protein-coupled receptor 62	2
Mouse	7	358	9 F1	Gpr62	G protein-coupled receptor 62
Rat	-	358	8q32	Gpr62	G protein-coupled receptor 62

Previous and Unofficial Names

GPCR8

Database Links
Specialist databases
GPCRdb	gpr62_human (Hs), gpr62_mouse (Mm), d4a2b1_rat (Rn)
Other databases
Alphafold	Q9BZJ7 (Hs), Q80UC6 (Mm), D4A2B1 (Rn)
ChEMBL Target	CHEMBL4523917 (Hs)
Ensembl Gene	ENSG00000180929 (Hs), ENSMUSG00000091735 (Mm), ENSRNOG00000022567 (Rn)
Entrez Gene	118442 (Hs), 436090 (Mm), 501049 (Rn)
Human Protein Atlas	ENSG00000180929 (Hs)
KEGG Gene	hsa:118442 (Hs), mmu:436090 (Mm), rno:501049 (Rn)
OMIM	606917 (Hs)
Pharos	Q9BZJ7 (Hs)
RefSeq Nucleotide	NM_080865 (Hs), NM_001159652 (Mm), XM_576464 (Rn)
RefSeq Protein	NP_543141 (Hs), NP_001153124 (Mm), XP_576464 (Rn)
UniProtKB	Q9BZJ7 (Hs), Q80UC6 (Mm), D4A2B1 (Rn)
Wikipedia	GPR62 (Hs)

Primary Transduction Mechanisms
Transducer	Effector/Response
Gs family
Comments:  Reported to couple constitutively to Gs
References:  3

Tissue Distribution
Brain regions (basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen) Species:  Human Technique:  Northern blot References:  2
Tissue Distribution Comments
Transcripts of GPR62 were not detected in the liver when examined by Northern blot analysis [2].

Physiological Consequences of Altering Gene Expression Comments

No overt phenotype [3] or impact on CNS myelination [1].

Biologically Significant Variants
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  V313L Global MAF (%):  11 Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 36|3|8|2 Minor allele count:  C=0.113/247 SNP accession:  rs323871 Validation:  1000 Genomes, HapMap, Frequency
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  S365R Global MAF (%):  1 Subpopulation MAF (%):  AFR: 5 Minor allele count:  G=0.011/24 Comment on frequency:  Low frequency (<10% in all tested populations) SNP accession:  rs116027996 Validation:  1000 Genomes, Frequency

General Comments
GPR62 has higher expression in the brain, indicating its cognate ligand may be a neurotransmitter [2].