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Plasmodium yoelii

Help on GtoMPdb Target Species Data

The GtoMPdb includes species information for antimalarial ligands and their target interactions.

Each individual Malaria Target Species page provides a detailed description of the species and a table displaying all interactions (contained in the database) associated with it.

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Species ID:121
Name:Plasmodium yoelii
Associated with:2 targets
3 ligands
Description
P. yoelii (Py) is a malaria parasite that infects mammals other than humans with the natural mammalian host being the thicket rat (G. surdaster) from Central Africa. Py is used in rodent model studies of malaria, in particular the immune response and in vaccine development.

Interactions

Interactions
Key to terms and symbols Click column headers to sort
Target Ligand Sp. Action Value Parameter Reference
Plasmodium falciparum phosphatidylinositol 4-kinase beta KDU691 Py

Plasmodium yoelii

P. yoelii (Py) is a malaria parasite that infects mammals other than humans with the natural mammalian host being the thicket rat (G. surdaster) from Central Africa. Py is used in rodent model studies of malaria, in particular the immune response and in vaccine development.
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 - 7.4 pIC50 3
pIC50 7.4 (IC50 3.6x10-8 M) Sporozoite hepatocyte invasion assay [3]
Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite)
Description: Parasite liver stage assay
Plasmodium falciparum lysyl-tRNA synthetase cladosporin Py

Plasmodium yoelii

P. yoelii (Py) is a malaria parasite that infects mammals other than humans with the natural mammalian host being the thicket rat (G. surdaster) from Central Africa. Py is used in rodent model studies of malaria, in particular the immune response and in vaccine development.
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 - 7.4 pIC50 1
pIC50 7.4 (IC50 3.91x10-8 M) Sporozoite hepatocyte invasion assay [1]
Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite)
Description: Parasite liver stage assay
Unknown MOA ganaplacide Py

Plasmodium yoelii

P. yoelii (Py) is a malaria parasite that infects mammals other than humans with the natural mammalian host being the thicket rat (G. surdaster) from Central Africa. Py is used in rodent model studies of malaria, in particular the immune response and in vaccine development.
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 - 8.7 pIC50 2
pIC50 8.7 (IC50 2x10-9 M) Sporozoite hepatocyte invasion assay [2]
Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite)
Description: Parasite liver stage assay

References

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1. Hoepfner D, McNamara CW, Lim CS, Studer C, Riedl R, Aust T, McCormack SL, Plouffe DM, Meister S, Schuierer S et al.. (2012) Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin. Cell Host Microbe, 11 (6): 654-63. [PMID:22704625]

2. Kuhen KL, Chatterjee AK, Rottmann M, Gagaring K, Borboa R, Buenviaje J, Chen Z, Francek C, Wu T, Nagle A et al.. (2014) KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission. Antimicrob Agents Chemother, 58 (9): 5060-7. [PMID:24913172]

3. McNamara CW, Lee MC, Lim CS, Lim SH, Roland J, Simon O, Yeung BK, Chatterjee AK, McCormack SL, Manary MJ et al.. (2013) Targeting Plasmodium PI(4)K to eliminate malaria. Nature, 504 (7479): 248-253. [PMID:24284631]