olamkicept

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Ligands
olamkicept

GtoPdb Ligand ID: 9729

Synonyms: FE 999301 | FE-301 | FE-999301 | TJ301

Compound class: Peptide

Comment: Olamkicept is a recombinant protein that fuses the extracellular domain of the signal transducing subunit of the IL-6 receptor, IL-6Rβ (glycoprotein 130, gp130), to a human IgG Fc fragment [3]. The full construct is a dimer of covalently linked identical peptide chains. Mechanistically olamkicept acts as an inhibitor of the IL-6 signalling pathway. Olamkicept inhibits trans signalling by the soluble IL-6 receptor (sIL-6R) [1], a mechanism that is involved in human inflammatory and autoimmune diseases [2]. It is hypothesised to be clinically effective in reducing disease signs and symptoms whilst not being detrimental to the role of IL-6 in the acute immune response to infection.

Immunopharmacology Comments
Olamkicept is a selective inhibitor of the IL-6 proinflammatory pathway. It blocks trans signaling that occurs via the soluble IL-6R (sIL-6R) and this action is effective against Crohn's disease and experimental colitis in vivo [1].

Immunopharmacology Comments

Olamkicept is a selective inhibitor of the IL-6 proinflammatory pathway. It blocks trans signaling that occurs via the soluble IL-6R (sIL-6R) and this action is effective against Crohn's disease and experimental colitis in vivo [1].

Immunopharmacology Disease
Disease	X-Refs	Comment	References
Ulcerative colitis	Disease Ontology: DOID:8577 OMIM: 266600 Orphanet: ORPHA771	Phase 2 clinical candidate for active UC- see NCT03235752.