QWF   Click here for help

GtoPdb Ligand ID: 9568

Synonyms: Boc-Gln-D-Trp(CH0)-Phe-OBzl | Nα-[Nα-[Nα-(tert-butyloxycabonyl)-L-glutaminyl]-N1-formyl-D-tryptophyl-L-phenylalanine benzyl ester
Immunopharmacology Ligand
Compound class: Peptide
Comment: QWF was originally identified as a tripeptide derivative of the substance P-derived octapeptide and NK1 receptor selective antagonist D-Pro-Gln-Gln-D-TrpPhe-D-Trp-D-Trp-Phe-NH2 [2]. It has more recently been reported to antagonise MRGPRX2 [1], and is claimed in patent WO2016118632 which covers the use of QWF derivatives as MRGPRX2 antagonists for the prevention and treatment of itch [3].
Bioactivity Comments
QWF is rapidly metabolized in plasma which limits its in vivo efficacy.
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
MRGPRX2 Hs Antagonist Antagonist - - - 1
⤷ [1]