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andexanet alfa   Click here for help

GtoPdb Ligand ID: 7576

Synonyms: Andexxa® | coagulation factor Xa (recombinant), inactivated-zhzo | Ondexxya® | PRT064445 | PRT4445 | r-antidote
Approved drug
andexanet alfa is an approved drug (FDA (2018), EMA (2019))
Compound class: Peptide
Comment: Andexanet alfa is a recombinant modified human Factor Xa (FXa) protein that acts as a mimetic of endogenous human factor Xa, and which was developed as a universal antidote to reverse thhe anticoagulant effects of direct or indirect FXa inhibitors. Information regarding the invention of andexanet alfa is available in patent WO2009042962 [2].
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View more information in the IUPHAR Pharmacology Education Project: andexanet alfa

Classification Click here for help
Compound class Peptide
Approved drug? Yes. EU EMA (2019)  |  US FDA (2018)
International Nonproprietary Names Click here for help
INN number INN
9883 andexanet alfa
Synonyms Click here for help
Andexxa® | coagulation factor Xa (recombinant), inactivated-zhzo | Ondexxya® | PRT064445 | PRT4445 | r-antidote
Database Links Click here for help
GtoPdb PubChem SID 223365912
Search PubMed clinical trials andexanet alfa
Search PubMed titles andexanet alfa
Search PubMed titles/abstracts andexanet alfa
UniParc UPI0001AD5DCA
Wikipedia Andexanet_alfa