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filgrastim   Click here for help

GtoPdb Ligand ID: 6968

Synonyms: Filcad® | Imumax ® | R-METHUG-CSF
Approved drug Immunopharmacology Ligand
filgrastim is an approved drug (FDA (1991))
Compound class: Peptide
Comment: This is a recombinant version of human G-CSF. The peptide is produced in E. coli and is non-glycosylated, whereas the naturally occurring peptide has an O-linked carbohydrate chain attached to Thr133. The carbohydrate chain protects the native peptide from degradation by human neutrophil elastase [1]. Therefore, filgrastim is more quickly degraded and loses biological activity more rapidly in comparison to native G-CSF.

Biosimilar drugs: The potential for utilising filgrastim biosimilar agents in neutropenia management is discussed in [2].

NameTrade name CompanyApprovalsIndications
filgrastim-sndzZarxio®SandozUS FDA 2015, EU EMA 2025As per reference agent
filgrastim-aafiNivestym® PfizerUS FDA 2018As per reference agent
filgrastim-ayowReleuko® Amneal PharmaceuticalsUS FDA 2022As per reference agent
filgrastim-txid; TX01Nypozi®Tanvex BioPharmaCanada CDA-AMC 2022, US FDA 2024 As per reference agent
filgrastim biosimilar Zefylti® CuraTeQ Biologics/Aurobindo PharmaEU EMA 2025 As per reference agent
filgrastim-laha Filkri® Accord BioPharmaUS FDA 2026 As per reference agent

In the EU 7 filgrastim biosimilars received marketing authorisation between 2008 and 2014 (Ratiograstim®, Tevagrastim®, Filgrastim Hexal®, Zarzio®, Nivestim®, Grastofil® and Accofil®, in order of approval), although some of these have since been withdrawn from the market.
Classification Click here for help
Compound class Peptide
Approved drug? Yes. US FDA (1991)
WHO Essential Medicine WHO Essential Medicines List (EML) (24th List, 2025). Download PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
International Nonproprietary Names Click here for help
INN number INN
6739 filgrastim
Synonyms Click here for help
Filcad® | Imumax ® | R-METHUG-CSF
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 631
Other databases
ChEMBL Ligand CHEMBL1201567
DrugBank Ligand DB00099
GtoPdb PubChem SID 178103548
Search PubMed clinical trials filgrastim
Search PubMed titles filgrastim
Search PubMed titles/abstracts filgrastim
Wikipedia Filgrastim