parawixin 1

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Ligands
parawixin 1

GtoPdb Ligand ID: 5352

Synonyms: PbTx1

Comment: Parawixin 1 is a bioactive HPLC-derived fraction of the toxin isolated from the venom of the spider Parawixia bistriata It is a mixture of complex organic compounds. Discrete active substances in Parawixin 1 are yet to be fully resolved [2].
Mechanism of action includes enhanced glutamate transport via activation of excitatory amino acid transporter 2 (EAAT2) in the brain [1].

References
1. Fontana AC, de Oliveira Beleboni R, Wojewodzic MW, Ferreira Dos Santos W, Coutinho-Netto J, Grutle NJ, Watts SD, Danbolt NC, Amara SG. (2007) Enhancing glutamate transport: mechanism of action of Parawixin1, a neuroprotective compound from Parawixia bistriata spider venom. Mol Pharmacol, 72 (5): 1228-37. [PMID:17646426]
2. Forster YM, Green JL, Khatiwada A, Liberato JL, Narayana Reddy PA, Salvino JM, Bienz S, Bigler L, Dos Santos WF, Karklin Fontana AC. (2020) Elucidation of the Structure and Synthesis of Neuroprotective Low Molecular Mass Components of the Parawixia bistriata Spider Venom. ACS Chem Neurosci, 11 (11): 1573-1596. [PMID:32343555]

References

1. Fontana AC, de Oliveira Beleboni R, Wojewodzic MW, Ferreira Dos Santos W, Coutinho-Netto J, Grutle NJ, Watts SD, Danbolt NC, Amara SG. (2007)
Enhancing glutamate transport: mechanism of action of Parawixin1, a neuroprotective compound from Parawixia bistriata spider venom.
Mol Pharmacol, 72 (5): 1228-37. [PMID:17646426]

2. Forster YM, Green JL, Khatiwada A, Liberato JL, Narayana Reddy PA, Salvino JM, Bienz S, Bigler L, Dos Santos WF, Karklin Fontana AC. (2020)
Elucidation of the Structure and Synthesis of Neuroprotective Low Molecular Mass Components of the Parawixia bistriata Spider Venom.
ACS Chem Neurosci, 11 (11): 1573-1596. [PMID:32343555]