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5-aminolevulinic acid   Click here for help

GtoPdb Ligand ID: 4784

Synonyms: 5-aminolevulinate | Ameluz® | D-aminolevulinic acid | Gliolan® | Levulan®
Approved drug PDB Ligand
5-aminolevulinic acid is an approved drug (FDA (1999)m EMA (2007))
Compound class: Metabolite
Comment: Approved as aminolevulinic acid

5-aminolevulinic acid is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 80.39
Molecular weight 131.06
XLogP -1.55
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES NCC(=O)CCC(=O)O
Isomeric SMILES NCC(=O)CCC(=O)O
InChI InChI=1S/C5H9NO3/c6-3-4(7)1-2-5(8)9/h1-3,6H2,(H,8,9)
InChI Key ZGXJTSGNIOSYLO-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Metabolite
Approved drug? Yes. US FDA (1999)  |  EU EMA (2007)
IUPAC Name Click here for help
5-amino-4-oxopentanoic acid
Synonyms Click here for help
5-aminolevulinate | Ameluz® | D-aminolevulinic acid | Gliolan® | Levulan®
Database Links Click here for help
CAS Registry No. 106-60-5
ChEBI CHEBI:17549
ChEMBL Ligand CHEMBL601
DrugBank Ligand DB00855
DrugCentral Ligand 166
GtoPdb PubChem SID 178101486
LIPID MAPS LMFA01100055
PubChem CID 137
RCSB PDB Ligand FVT
Search Google for chemical match using the InChIKey ZGXJTSGNIOSYLO-UHFFFAOYSA-N
Search Google for chemicals with the same backbone ZGXJTSGNIOSYLO
UniChem Compound Search for chemical match using the InChIKey ZGXJTSGNIOSYLO-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey ZGXJTSGNIOSYLO-UHFFFAOYSA-N
Wikipedia Aminolevulinic_acid

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MedChemExpress
5-Aminolevulinic acid (links to external site)
Cat. No. HY-W000450