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calciseptine   Click here for help

GtoPdb Ligand ID: 4149

Compound class: Peptide
Comment: From the venom gland of Dendroaspis polylepis polylepis (Black mamba)
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Barrere C, Chinda K, Mesirca P, Aurelie C, Diochot S, Lazdunsk M, Barrere-Lamaire S, Mangoni M, Nargeot J. (2020)
Evidence for a selective blockade of Cav1.2 versus Cav1.3 by the mamba toxin calciseptine in the mouse heart.
Archives of Cardiovascular Diseases Supplements, 12 (2-4): 259. DOI: 10.1016/j.acvdsp.2020.03.144
2. de Weille JR, Schweitz H, Maes P, Tartar A, Lazdunski M. (1991)
Calciseptine, a peptide isolated from black mamba venom, is a specific blocker of the L-type calcium channel.
Proc Natl Acad Sci U S A, 88 (6): 2437-40. [PMID:1848702]
3. Mesirca P, Chemin J, Barrère C, Torre E, Gallot L, Monteil A, Bidaud I, Diochot S, Lazdunski M, Soong TW et al.. (2024)
Selective blockade of Cav1.2 (α1C) versus Cav1.3 (α1D) L-type calcium channels by the black mamba toxin calciseptine.
Nat Commun, 15 (1): 54. [PMID:38167790]
4. Watanabe TX, Itahara Y, Kuroda H, Chen YN, Kimura T, Sakakibara S. (1995)
Smooth muscle relaxing and hypotensive activities of synthetic calciseptine and the homologous snake venom peptide FS2.
Jpn J Pharmacol, 68 (3): 305-13. [PMID:7474554]