paricalcitol   Click here for help

GtoPdb Ligand ID: 2791

Synonyms: Zemplar®
Approved drug
paricalcitol is an approved drug (FDA (1998))
Compound class: Metabolite or derivative
Comment: Vitamin D receptor agonist

paricalcitol is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 60.69
Molecular weight 416.33
XLogP 6.14
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES OC1CC(O)CC(=CC=C2CCCC3(C2CCC3C(C=CC(C(O)(C)C)C)C)C)C1
Isomeric SMILES O[C@H]1C[C@H](O)CC(=C/C=C/2\CCC[C@]3([C@H]2CC[C@@H]3[C@@H](/C=C/[C@@H](C(O)(C)C)C)C)C)C1
InChI InChI=1S/C27H44O3/c1-18(8-9-19(2)26(3,4)30)24-12-13-25-21(7-6-14-27(24,25)5)11-10-20-15-22(28)17-23(29)16-20/h8-11,18-19,22-25,28-30H,6-7,12-17H2,1-5H3/b9-8+,21-11+/t18-,19+,22-,23-,24-,25+,27-/m1/s1
InChI Key BPKAHTKRCLCHEA-UBFJEZKGSA-N
Classification Click here for help
Compound class Metabolite or derivative
Approved drug? Yes (FDA (1998))
IUPAC Name Click here for help
(1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-6-hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol
International Nonproprietary Names Click here for help
INN number INN
7688 paricalcitol
Synonyms Click here for help
Zemplar®
Database Links Click here for help
CAS Registry No. 131918-61-1 (source: Scifinder)
ChEMBL Ligand CHEMBL1200622
DrugBank Ligand DB00910
DrugCentral Ligand 2066
GtoPdb PubChem SID 135651536
PubChem CID 5281104
Search Google for chemical match using the InChIKey BPKAHTKRCLCHEA-UBFJEZKGSA-N
Search Google for chemicals with the same backbone BPKAHTKRCLCHEA
Search PubMed clinical trials paricalcitol
Search PubMed titles paricalcitol
Search PubMed titles/abstracts paricalcitol
UniChem Compound Search for chemical match using the InChIKey BPKAHTKRCLCHEA-UBFJEZKGSA-N
UniChem Connectivity Search for chemical match using the InChIKey BPKAHTKRCLCHEA-UBFJEZKGSA-N
Wikipedia Paricalcitol

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Tocris
Paricalcitol (links to external site)
Cat. No. 4161