capsaicin   Click here for help

GtoPdb Ligand ID: 2486

Synonyms: Qutenza®
Approved drug PDB Ligand
capsaicin is an approved drug (EMA & FDA (2009))
Compound class: Natural product or derivative
Comment: Although capsaicin was approved by the US FDA in 2009, this compound was previously marketed so was not subject to a New Drug Application.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

capsaicin is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 58.56
Molecular weight 305.2
XLogP 4.32
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES COc1cc(CNC(=O)CCCCC=CC(C)C)ccc1O
Isomeric SMILES COc1cc(CNC(=O)CCCC/C=C/C(C)C)ccc1O
InChI InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+
InChI Key YKPUWZUDDOIDPM-SOFGYWHQSA-N
Classification Click here for help
Compound class Natural product or derivative
Approved drug? Yes (EMA & FDA (2009))
IUPAC Name Click here for help
N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
International Nonproprietary Names Click here for help
INN number INN
10145 capsaicin
Synonyms Click here for help
Qutenza®
Database Links Click here for help
BindingDB Ligand 20461
CAS Registry No. 404-86-4
ChEBI CHEBI:3374
ChEMBL Ligand CHEMBL294199
DrugCentral Ligand 3064
GtoPdb PubChem SID 53801090
PubChem CID 1548943
RCSB PDB Ligand 4DY
Search Google for chemical match using the InChIKey YKPUWZUDDOIDPM-SOFGYWHQSA-N
Search Google for chemicals with the same backbone YKPUWZUDDOIDPM
Search PubMed clinical trials capsaicin
Search PubMed titles capsaicin
Search PubMed titles/abstracts capsaicin
UniChem Compound Search for chemical match using the InChIKey YKPUWZUDDOIDPM-SOFGYWHQSA-N
UniChem Connectivity Search for chemical match using the InChIKey YKPUWZUDDOIDPM-SOFGYWHQSA-N
Wikipedia Capsaicin

Product suppliers

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Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.

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Tocris
(E)-Capsaicin (links to external site)
Cat. No. 0462