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GtoPdb Ligand ID: 2346

Synonyms: hydrogen ion
Compound class: Inorganic
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Natural/Endogenous Targets
Target
ASIC1
ASIC2
ASIC3
glycine receptor α1 subunit
ZAC
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Kir2.4 Ligand is endogenous in the given species Hs Gating inhibitor (Extracellular H+) Antagonist 7.1 pKi - 3
⤷ pKi 7.1 [3]
Voltage: -120.0 mV
Kir2.3 Ligand is endogenous in the given species Hs Gating inhibitor (Extracellular H+) Antagonist 6.7 – 7.4 pKi - 1,6,11
⤷ pKi 6.7 – 7.4 [1,11]
Voltage: -120.0 – -100.0 mV
pKi 6.8 – 6.8 [6,11]
Voltage: -150.0 – 100.0 mV
Kir4.2 Rn Gating inhibitor (Intracellular H+) Antagonist 6.7 – 7.1 pEC50 - 5
⤷ pEC50 6.7 – 7.1 [5]
Voltage: -100.0 mV
Kir4.1 Ligand is endogenous in the given species Rn Gating inhibitor (Intracellular H+) Antagonist 6.0 – 6.1 pEC50 - 5,10
⤷ pEC50 6.0 – 6.1 [5,10]
Voltage: -100.0 mV
ASIC1 Ligand is endogenous in the given species Hs Activator (Extracellular H+) - ~5.1 – 6.8 pEC50 -
⤷ pEC50 ~6.2 – 6.8 (EC50 ~6.3x10-7 – 1.6x10-7 M) ASIC1a
pEC50 ~5.1 – 6.2 (EC50 ~8x10-6 – 6.3x10-7 M) ASIC1b
ZAC Ligand is endogenous in the given species Hs Agonist Agonist 5.6 pEC50 - 8
⤷ pEC50 5.6 [8]
TRPV1 Ligand is endogenous in the given species Hs Activator (extracellular H+) - 5.4 pEC50 -
⤷ pEC50 5.4 (EC50 3.98x10-6 M) at 37°C
ASIC3 Ligand is endogenous in the given species Hs Activator (Extracellular H+) - ~3.5 – 6.7 pEC50 -
⤷ pEC50 ~6.2 – 6.7 (EC50 ~6.3x10-7 – 2x10-7 M) transient component
pEC50 ~3.5 – 4.3 (EC50 ~3.5x10-4 – 5x10-5 M) sustained component
ASIC2 Ligand is endogenous in the given species Hs Activator (Extracellular H+) - ~4.1 – 5.0 pEC50 -
⤷ pEC50 ~4.1 – 5.0 (EC50 ~8x10-5 – 1x10-5 M)
TRPM7 Ligand is endogenous in the given species Hs Activator (Extracellular H+) Potentiation 4.5 pEC50 - 4
⤷ pEC50 4.5 [4]
Kir1.1 Ligand is endogenous in the given species Rn Gating inhibitor (Intracellular H+) Antagonist 6.8 pIC50 - 2,7,9
⤷ pIC50 6.8 [2,7,9]
Voltage: -160.0 – -40.0 mV
TRPM5 Hs Channel blocker (Extracellular H+) - 3.2 pIC50 -
⤷ pIC50 3.2 (IC50 6.3x10-4 M)
glycine receptor α1 subunit Ligand is endogenous in the given species Hs Allosteric modulator (Extracellular H+) Inhibition - - -
⤷ endogenous
TRPC6 Hs Channel blocker (Extracellular H+) - - - -
⤷
TRPM2 Ligand is endogenous in the given species Hs Channel blocker (extracellular H+) - - - -
⤷
TRPM6 Ligand is endogenous in the given species Hs Activator (extracellular H+) Potentiation - - -
⤷ μM range
Ligand mentioned in the following text fields
ZAC overview