APB-R3

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Ligands
APB-R3

GtoPdb Ligand ID: 13869

Compound class: Peptide

Comment: APB-R3 is a long-acting recombinant interleukin 18 binding protein (IL-18BP) mimetic [1]. The IL-18BP amino acid sequence has been optimised for IL-18 binding, and it is linked to the Fab fragment of an anti-human serum albumin antibody to extend its circulating half-life.

Summary
Biological activity
References
Immunopharmacology

Immunopharmacology Comments
APB-R3 alleviates skin inflammation in a model of atopic dermatitis and liver inflammation and splenomegaly in a model of metabolic dysfunction-associated steatohepatitis (MASH) [1].

Immunopharmacology Comments

APB-R3 alleviates skin inflammation in a model of atopic dermatitis and liver inflammation and splenomegaly in a model of metabolic dysfunction-associated steatohepatitis (MASH) [1].