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APB-R3   Click here for help

GtoPdb Ligand ID: 13869

Immunopharmacology Ligand
Compound class: Peptide
Comment: APB-R3 is a long-acting recombinant interleukin 18 binding protein (IL-18BP) mimetic [1]. The IL-18BP amino acid sequence has been optimised for IL-18 binding, and it is linked to the Fab fragment of an anti-human serum albumin antibody to extend its circulating half-life.
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
IL-18 Hs None Binding 7.2 pKd - 1
⤷ pKd 7.2 (Kd 6.09x10-8 M) [1]