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PDEF(98-114)H105A   Click here for help

GtoPdb Ligand ID: 13832

Compound class: Peptide
Comment: This is a 17 amino acid derivative of pigment epithelium-derived factor [1]. It was designed for optimised penetration into the retina in an eye drops formulation, to combat retinal degeneration by promoting survival of photoreceptor expressing retinal cells.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Bernardo-Colón A, Bighinati A, Parween S, Debnath S, Piano I, Adani E, Corsi F, Gargini C, Vergara N, Marigo V et al.. (2025)
H105A peptide eye drops promote photoreceptor survival in murine and human models of retinal degeneration.
Commun Med (Lond), 5 (1): 81. [PMID:40118996]
2. Kenealey J, Subramanian P, Comitato A, Bullock J, Keehan L, Polato F, Hoover D, Marigo V, Becerra SP. (2015)
Small Retinoprotective Peptides Reveal a Receptor-binding Region on Pigment Epithelium-derived Factor.
J Biol Chem, 290 (42): 25241-53. [PMID:26304116]