consomatin Fj1   Click here for help

GtoPdb Ligand ID: 13681

Compound class: Peptide
Comment: Consomatin Fj1 is a cyclic decapeptide produced by the marine cone snail Conus fijisulcatus. It is proposed as naturally evolved analogue of an endogenous somatostatin (SST)-like signalling peptide. Consomatin Fj1 acts as a mimetic of the endogenous human hormone somatostatin, and is an agonist of the SST4 receptor that promotes G protein dissociation from the receptor [1].
SST4 is expressed by peripheral sensory neurons and SST4-mediated antinociception is being pursued as a promising mechanism for non-opioid pain relief.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Bioactivity Comments
In vitro, consomatin Fj1 is >170-fold selective for SST4 compared to SST1, and has no detectable activity at the other three SST receptor subtypes [1].
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
SST4 receptor Hs Agonist Agonist 7.7 pEC50 - 1
⤷ pEC50 7.7 (EC50 2.2x10-8 M) [1]