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Apta-1   Click here for help

GtoPdb Ligand ID: 13556

Immunopharmacology Ligand Antimalarial Ligand
Compound class: Nucleic acid
Comment: Apta-1 is a 90-mer RNA aptamer that is designed to bind to a conserved region of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) as a mechanism to disrupt infectivity [1]. It contains 2'-OH RNA purine nucleotides and 2'-fluoro pyrimidine nucleotides (marked as 'f' in the sequence provided here). Apta-1 is also reported to bind to the heparin-binding exosite II of thrombin, which drives significant inhibition of protease-activated receptor (PAR) signalling in platelets and antithrombotic sequelae [4].
Classification Click here for help
Compound class Nucleic acid
Compound subclass Aptamer
Target PfEMP1
Ligand families/groups Antimalarial ligands
Database Links Click here for help
GtoPdb PubChem SID 500839966