oroxylin A   Click here for help

GtoPdb Ligand ID: 13522

Immunopharmacology Ligand
Compound class: Natural product
Comment: Oroxylin A is an active phytochemical that can be isolated from the Chinese herb Huang-Chi (Astragalus mongholicus; Mongolian milkvetch in English) and other herbal plants such as Scutellaria baicalensis. It has demonstrated anti-inflammatory [3,5-6,8], anti-infection [2,7] and anti-tumour activities [9] in experimental models, which suggests therapeutic potential in human diseases [4].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 75.99
Molecular weight 284.26
XLogP 1.82
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES COC1=C(C=C2C(=C1O)C(=O)C=C(C3=CC=CC=C3)O2)O
Isomeric SMILES COC1=C(C2=C(C=C1O)OC(=CC2=O)C3=CC=CC=C3)O
InChI InChI=1S/C16H12O5/c1-20-16-11(18)8-13-14(15(16)19)10(17)7-12(21-13)9-5-3-2-4-6-9/h2-8,18-19H,1H3
InChI Key LKOJGSWUMISDOF-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Chin YW, Kong JY, Han SY. (2013)
Flavonoids as receptor tyrosine kinase FLT3 inhibitors.
Bioorg Med Chem Lett, 23 (6): 1768-70. [PMID:23411073]
2. Gao J, Ding Y, Wang Y, Liang P, Zhang L, Liu R. (2021)
Oroxylin A is a severe acute respiratory syndrome coronavirus 2-spiked pseudotyped virus blocker obtained from Radix Scutellariae using angiotensin-converting enzyme II/cell membrane chromatography.
Phytother Res, 35 (6): 3194-3204. [PMID:33587321]
3. Li J, Tong D, Liu J, Chen F, Shen Y. (2016)
Oroxylin A attenuates cigarette smoke-induced lung inflammation by activating Nrf2.
Int Immunopharmacol, 40: 524-529. [PMID:27764743]
4. Sajeev A, Hegde M, Girisa S, Devanarayanan TN, Alqahtani MS, Abbas M, Sil SK, Sethi G, Chen JT, Kunnumakkara AB. (2022)
Oroxylin A: A Promising Flavonoid for Prevention and Treatment of Chronic Diseases.
Biomolecules, 12 (9). [PMID:36139025]
5. Wang T, Wang ZB, Jiang CM, Zhao Y, Tang L, Xiao XM, Fu J. (2024)
Oroxylin A inhibits inflammatory cytokines in periodontitis via HO‑1.
Mol Med Rep, 30 (1). [PMID:38785151]
6. Wang YL, Gao JM, Xing LZ. (2016)
Therapeutic potential of Oroxylin A in rheumatoid arthritis.
Int Immunopharmacol, 40: 294-299. [PMID:27643663]
7. Yin L, Bing Z, Zheng Y, Pan Y, Dong Y, Wang J, Luo R, Zhao Y, Dou H, Hou Y. (2024)
Oroxylin A-induced Trained Immunity Promotes LC3-associated Phagocytosis in Macrophage in Protecting Mice Against Sepsis.
Inflammation, 47 (6): 2196-2214. [PMID:38739341]
8. Zhang Y, Weng Q, Chen J, Li M, Han J. (2021)
Oroxylin A attenuates IL-1β-induced inflammatory reaction via inhibiting the activation of the ERK and PI3K/AKT signaling pathways in osteoarthritis chondrocytes.
Exp Ther Med, 21 (4): 388. [PMID:33680110]
9. Zhao Y, Zhu Q, Bu X, Zhou Y, Bai D, Guo Q, Gao Y, Lu N. (2020)
Triggering apoptosis by oroxylin A through caspase-8 activation and p62/SQSTM1 proteolysis.
Redox Biol, 29: 101392. [PMID:31926620]