YH35324   Click here for help

GtoPdb Ligand ID: 13448

Synonyms: IgETRAP | YH-35324
Immunopharmacology Ligand
Compound class: Peptide
Comment: YH35324 is a long-acting IgETrap-Fc fusion protein, that links the extracellular domain of human high-affinity IgE receptor (hFcεRI) to an IgD/IgG4 hybrid Fc domain [2]. It targets human IgE as a mechanistic approach for disease-modifying potential in IgE-mediated allergic diseases.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. An SB, Yang BG, Jang G, Kim DY, Kim J, Oh SM, Oh N, Lee S, Moon JY, Kim JA et al.. (2022)
Combined IgE neutralization and Bifidobacterium longum supplementation reduces the allergic response in models of food allergy.
Nat Commun, 13 (1): 5669. [PMID:36167830]
2. Ye YM, Park JW, Kim SH, Cho YS, Lee SY, Lee SY, Sim S, Song E, Kim B, Lee J et al.. (2024)
Safety, Tolerability, Pharmacokinetics, and pharmacodynamics of YH35324, a novel Long-Acting High-Affinity IgETrap-Fc protein in subjects with Atopy: Results from the First-in-Human study.
Int Immunopharmacol, 130: 111706. [PMID:38382265]