YH35324   Click here for help

GtoPdb Ligand ID: 13448

Synonyms: IgETRAP | YH-35324
Immunopharmacology Ligand
Compound class: Peptide
Comment: YH35324 is a long-acting IgETrap-Fc fusion protein, that links the extracellular domain of human high-affinity IgE receptor (hFcεRI) to an IgD/IgG4 hybrid Fc domain [2]. It targets human IgE as a mechanistic approach for disease-modifying potential in IgE-mediated allergic diseases.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
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Summary of Clinical Use Click here for help
YH35324 is in clinical evaluation for potential to treat IgE-mediated (atopic) allergic diseases.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT05960708 A Single Dose, Phase 1 Study of YH35324 in Patients With Various Allergic Diseases Phase 1 Interventional Yuhan Corporation
NCT05061524 A FIH Study of YH35324 in Atopic Healthy Subjects or Subjects With Mild Allergic Diseases Phase 1 Interventional Yuhan Corporation 2